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Objective A wireless power supply system suitable for implantable medical devices is proposed.This paper introduces magnetic resonance coupling energy supply method to implantable power supply system, and calculates coil size and resonance frequency through setting up theoretic coil simulation model in order to solve the problems as long distance and small size of wireless power supply to enable the implantable devices to be used for the whole life without replacing batteries.Methods Coupling resonance coil model and wireless energy transmission model are firstly simulated through MATLAB, and the optimal coil design is calculated.And then, transmitting coil and receiving coil are made according to the simulation results, which make the system with the optimal transmitting efficiency under limited distance.Results The simulation algorithm can effectively describe the magnetic coupling resonance.Average relative errors of Q and L in theory and actuality are calculated and measured, EQ=5.34% EL=4.42%, providing reference basis for the design of actual power supply system.This design realizes mini power supply system suitable for medical implantable devices with increasing transmission distance.Big-to-small coil design is adopted, and size of the implantable part is only 18mm with external coil diameter of 85mm.The transmission efficiency of this design actually reaches 16.20% to the highest, and 2.642mW can be supplied at a distance of 88mm.Conclusions The simulation method provides a reference for the coupling resonance design and is a new design for implantable medical systems.