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不同電極距離下人體小腿組織細(xì)胞內(nèi)外液電阻率的測量

Measurement of the resistivity of extracellular and intracellularfluids in lower leg at different electrode distances

作者: 古菲菲  王燕平  王廣軍  趙朋娜  魏玉龍  張維波 
單位:新奧集團(tuán)新繹健康科技有限公司(河北廊坊<p>065001)</p><p></p>
關(guān)鍵詞: 生物阻抗譜;細(xì)胞外液;細(xì)胞內(nèi)液;電阻率;人體 
分類號(hào):R318.04
出版年·卷·期(頁碼):2017·36·6(601-606)
摘要:

目的 觀察不同電極距離下人體小腿細(xì)胞內(nèi)外液電阻率的均勻性,探究測量系統(tǒng)的可行性,以便應(yīng)用此系統(tǒng)測量健康信息。方法 采用四電極生物阻抗譜法,激勵(lì)電極將1~100kHz恒流電流施加到人體小腿兩端,測量電極采集電壓和相角,電極距離分別為5cm、10cm、15cm。測量10例健康受試者,計(jì)算得到細(xì)胞內(nèi)外液的阻抗值和電阻率。結(jié)果 隨兩電極間距離的增加,細(xì)胞內(nèi)外液阻抗均極顯著增加,阻抗的增加與距離高度相關(guān);細(xì)胞內(nèi)外液電阻率隨距離僅有小幅增加,5cm和15cm之間有顯著性差異,與小腿有效截面積隨距離縮小有關(guān)。細(xì)胞內(nèi)外液電阻率之比接近1 ,且不隨電極距離的變化而改變。結(jié)論 健康人體小腿組織的電阻率比較均勻,細(xì)胞內(nèi)外液電阻率基本相等。

Objective To explore the feasibility of tissue fluid resistivity measurement for healthcare management, we evaluated the uniformity of the extracellular (ρe) and intracellular (ρi) fluid resistivity in a lower leg (by measuring at different electrode distances). Methods Ten health volunteers were involved in the test with a four-electrode bioimpedance spectroscopy. The measurement was performed with excitation frequencies from 1kHz to 100kHz. Two measuring electrodes were set on one lower leg at the distances of 5cm, 10cm and 15cm. Voltage amplitude, phase angle, ρe and ρi were analyzed. Results The measured impedance increased with the distance of the measuring electrodes, and the resistivity changed little with the distance. No obvious difference between extracellular and intracellular fluid resistivity was observed. In addition, voltage amplitude and phase angle were influenced by the frequencies of excitation signals. Conclusions The resistivity in a lower leg measured with the four-electrode bioimpedance spectroscopy is likely uniform. The resistivities of extracellular fluid and intracellular fluid are similar.

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