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左主干分叉病變嚴重程度的血流動力學(xué)功能性評價

Hemodynamic functional evaluation of severity in left main bifurcation lesion

作者: 張慧霞  王浩然  毛伯龑  劉有軍 
單位:<span style="font-family:宋體">北京工業(yè)大學(xué)生命科學(xué)與生物工程學(xué)院(北京</span>100124<span style="font-family:宋體">)</span>
關(guān)鍵詞: 關(guān)鍵詞:左主干分叉病變;  幾何多尺度計算;  流量;  壁面切應(yīng)力;  壁面切應(yīng)力振蕩指數(shù) 
分類號:R318.01
出版年·卷·期(頁碼):2018·37·3(221-227)
摘要:

Objective The choice of treatment for unprotected left main bifurcation lesions depends largely on the severity of the lesion. SYNTAX score is a kind of severity of coronary artery disease evaluation method, which is based on coronary angiography and a complete anatomical evaluation. In this paper, the total perfusion is regarded as a reference to determine the severity of the lesion. From the perspective of hemodynamics, the severity of different types of bifurcation lesions is assessed. Methods The geometric multi-scale numerical simulation of different bifurcation lesions was carried out by coupling 3D model of the patient and the lumped parameter model. The flow of different branches, wall shear stress( WSS, oscillatory shear index( OSI was extracted. By comparing these parameters, the severity of different types of bifurcation lesions was analyzed. Results The results showed that whether the branch (circumflex) the stenosis existed or not had an effect on the total perfusion. When the branch had lesion, the total perfusion volume decreased, which was consistent with the classification of the bifurcation lesion in the SYNTAX score. From the risk of deterioration, when the left main (LM) was stenosis, the average WSS of the bifurcation area was relatively large, but OSI did not show a certain law. Conclusion The total perfusion of branch stenosis is smaller than branch normal. So the degree of myocardial ischemia of branch stenosis is more serious, but the risk of further development of stenosis has no significant difference.

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