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 Objective In order to prepare bioactive bone tissue scaffolds with certain mechanical strength and osteogenic guiding function to meet the needs of bone tissue engineering, we use 45 S5 bioactive glass as raw material to prepare three-dimensional active porous scaffold of bone tissue engineering with digital light processing ( DLP) and high temperature sintering. The molding effect and mechanical properties are also analyzed and verified. Methods By taking the 45 S5 bioactive glass as main material and mixing with the photosensitive resin, the three dimensional porous scaffolds are designed and fabricated based on DLP method, then the bioactive scaffolds of bone tissue engineering are fabricated by the optimized sintering process. SEM and MTS are used to analyze the morphology and structural characteristics of the scaffolds, and the porosity and mechanical properties of the scaffolds also are studied. Results This method can fabricate bioactive scaffold with complex predesigned porous structure more accurately than other scaffold preparation methods. For the proposed scaffold, the pore size is about 400 μm, the porosity reaches 55. 79%, and the compressive strength is 10 MPa to 14 MPa. These performances show that the proposed scaffold can meet the requirement of the bone tissue engineering scaffold. Furthermore, on the surface of theproposed scaffold, there are many uniform pores with diameters about 0. 5 μm. Cooperating with the microscopic pores, the macro pores can improve the ability of bone tissue repair for the proposed scaffold.Conclusions The bioactive scaffolds prepared by this method can be applied to bone tissue engineering.