北京生物醫(yī)學(xué)工程

重離子放射治療技術(shù)及臨床應(yīng)用

Technology and clinical application of heavy ion radiation therapy

作者：王曉林高天欣韓瀟陳曉君唐曉英

單位：北京理工大學(xué)生命學(xué)院(北京 100081)

關(guān)鍵詞：重離子；放射治療；癌癥；臨床應(yīng)用

分類號(hào)：R318

出版年·卷·期（頁碼）：2019·38·3（312-318）

摘要：

重離子的細(xì)胞殺傷作用大，有倒轉(zhuǎn)劑量分布優(yōu)勢(shì)，而且具有拓展布拉格峰、高傳能線密度、高相對(duì)生物效應(yīng)等特點(diǎn)。將其應(yīng)用于癌癥治療，可使深部區(qū)域腫瘤細(xì)胞因高劑量輻射而被有效殺滅，而對(duì)周圍組織因低劑量分布、相對(duì)危害較小，能實(shí)現(xiàn)精確靶向治療，這也被認(rèn)為是最有前景的腫瘤放療技術(shù)。本文簡(jiǎn)要介紹了重離子放射治療的物理和生物學(xué)特征，回顧了重離子放射治療的發(fā)展歷程及現(xiàn)狀；重點(diǎn)闡述了重離子放射治療技術(shù)在臨床的應(yīng)用現(xiàn)狀及優(yōu)勢(shì)，以期為重離子輻射生物學(xué)的研究人員提供一定的數(shù)據(jù)參考和未來方向參考，更好地促進(jìn)重離子放射治療在臨床治癌中的良好應(yīng)用。

Heavy ions have the characteristics as high cytotoxicity,inverted dose distribution,expanded Bragg peak,high linear energy transfer,and high relative biological effectiveness. The precise targeted therapy can be achieved by using heavy ions to treat tumor,because it delivers high doses of radiation to the deep regions of tumor cells to efficiently kill them,yet causes relatively little damages to the surrounding tissues at low dose. Thus, heavy ion beam is deemed a most promising technology of tumor radiotherapy. This article briefly introduces the physical and biological characteristics of heavy ion radiation therapy, and reviews the development status of heavy ion radiation therapy. The paper focuses on the application status and advantages of heavy ion radiation therapy in the treatment of cancer. It is expected that this review may provide a reference for researchers in radiation biology of heavy ion to better estimate the risks of heavy ions to human health and promote the application in treatment of cancer.

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