北京生物醫(yī)學(xué)工程

不同材質(zhì)斑塊的狹窄頸動(dòng)脈模型中新型鋅合金支架的支撐性能研究

Support performance of new type zinc alloy stent in stenotic carotid arteries model with different materials plaques

作者：李子豪喬愛科王斯睿崔新陽

單位：北京工業(yè)大學(xué)生命科學(xué)與生物工程學(xué)院 ( 北京 100124)

關(guān)鍵詞：血管支架; 狹窄率; 頸動(dòng)脈; 數(shù)值模擬; 生物力學(xué)

分類號：R318.01

出版年·卷·期（頁碼）：2019·38·3（235-239）

摘要：

目的研究在不同斑塊類型的理想化狹窄頸動(dòng)脈模型中新型鋅合金支架的受力變形情況,為新型鋅合金支架的設(shè)計(jì)與應(yīng)用提供科學(xué)的參考意見。方法運(yùn)用 Pro / E 三維建模軟件構(gòu)建理想化的50%狹窄率血管模型和一種 I 型連接筋血管支架;利用 ABAQUS 有限元分析軟件,模擬支架受相同位移擴(kuò)張條件作用下分別在鈣化和非鈣化斑塊的理想化狹窄血管中的擴(kuò)張過程。通過計(jì)算支架狗骨頭率和殘余狹窄率評估支架的支撐性能? 結(jié)果在斑塊材料屬性分別為鈣化和非鈣化的模型中,支架擴(kuò)張階段的最大應(yīng)力分別為 433.4 MPa，432.4 MPa,回彈階段的最大應(yīng)力值分別為 266.1 MPa，259.4 MPa;支架狗骨頭率分別為 44.5%，33.3%,血管殘余狹窄率為 40.8%，30.2% 。結(jié)論支架在擴(kuò)張過程中受到的von Mises 應(yīng)力都小于材料的應(yīng)力強(qiáng)度極限,且血管狹窄率都有明顯的下降，對于兩種斑塊類型的狹窄血管,新型鋅合金支架都起到了一定的支撐作用。

Objective To study the deformation of new zinc alloy stents in idealized stenotic blood vessel models of different plaque types,and to provide scientific reference for the design and application of new zinc alloy stents.Methods Three?dimensional modeling method was used to construct idealized stenotic vascular model and a I?type connecting vascular stent. Finite element analysis software ABAQUS was used to simulate the process of stent expansion in an idealized stenosis with either calcified or non?calcified plaque and thestenosis rate of 50%.Results In the models with calcified and non?calcified plaque,the maximum stress during the stent expansion phase was 433.4 MPa and 432.4 MPa respectively,and the maximum stress values during the recoiling phase were 266.1 MPa and 259.4 MPa respectively. The dog?bone rate was 44.5% and 33.3% respectively, the residual stenosis rate was 40.8% and 30.2% respectively. Conclusions The von Mises stress of the stent during the expansion process is less than thestrength limit of the material, and the stenosis rate is significantly decreased.For the two types of plaque stenosis,the new zinc alloy stents have played a supporting role to achieve therapeutic effect,which provides guidance and reference for the development of zinc alloy stents.

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