北京生物醫(yī)學(xué)工程

基于衰減皮爾森相關(guān)的癲癇腦網(wǎng)絡(luò)動態(tài)分析方法

Attenuated Pearson correlation coefficient-based study on dynamic analysis method of Epileptic brain network

作者：李若松王尊升劉偉峰閆天翼王安聰孫偉唐曉英

單位：北京理工大學(xué)生命學(xué)院（北京100081）首都醫(yī)科大學(xué)宣武醫(yī)院神經(jīng)內(nèi)科（北京 100032）

關(guān)鍵詞：癲癇；腦網(wǎng)絡(luò)； SEEG；衰減皮爾森相關(guān)；替代數(shù)據(jù)檢驗

分類號：R318.04

出版年·卷·期（頁碼）：2019·38·5（457-464）

摘要：

目的致癇灶定位是難治性癲癇治療中的重要環(huán)節(jié)，本文通過應(yīng)用癲癇腦網(wǎng)絡(luò)的動態(tài)分析方法，輔助臨床進(jìn)行致癇灶定位及病理研究。方法使用5名難治性癲癇患者發(fā)作起始附近(發(fā)作前2 s到發(fā)作后4 s)的立體定向腦電（stereo electroencephalograph,SEEG）數(shù)據(jù)，基于衰減皮爾森相關(guān)系數(shù)與替代數(shù)據(jù)檢驗方法，對腦區(qū)間的功能連接進(jìn)行評估。通過加窗截斷實現(xiàn)動態(tài)腦網(wǎng)路構(gòu)建，對癲癇腦網(wǎng)絡(luò)進(jìn)行動態(tài)分析。結(jié)果在發(fā)作起始階段，致癇灶腦區(qū)間的正相關(guān)連接較強，致癇灶與非致癇灶間正相關(guān)連接較少，致癇灶之間與非致癇灶之間網(wǎng)絡(luò)連接模式具有差異性。結(jié)論致癇灶與非致癇灶之間的衰減皮爾森相關(guān)網(wǎng)絡(luò)連接模式具有差異，此方法對臨床致癇灶定位有一定輔助作用，此方法也適用于基于其他功能連接參數(shù)進(jìn)行腦網(wǎng)絡(luò)分析。

Objective The location of epileptogenic zone is an important step in refractory epilepsy surgery. In this paper, we achieve a dynamic analysis method of epileptic brain network in order to improve the localization of epileptogenic zone and pathological study of epilepsy. Methods Based on attenuated Pearson correlation coefficient and alternative data test methods, we used stereo-electroencephalography (SEEG) data（from 2 seconds before seizure onset to 4 seconds after seizure onset） from 5 patients with refractory epilepsy to assess functional connectivity in the brain. Based on windowed truncation, we built dynamic brain networks and performed dynamic analysis of epilepsy brain network. Results At the initial stage of seizure, the positive correlation between epileptogenic zone was strong, there was less positive correlation between epileptogenic zone and non- epileptogenic zone ,and the network connection pattern between epileptogenic zone and non- epileptogenic zone was different. Conclusions There is a difference in the attenuated Pearson correlation network connection between epileptogenic zone and non- epileptogenic zone.This method has auxiliary effect on the localization of epileptogenic zone, and is also applicable to brain network analysis based on other functional connection parameters.

參考文獻(xiàn)：

[1] Fisher RS, Boas WV, Blume W, et al. Epileptic seizures and epilepsy: Definitions proposed by the International League against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE) [J]. Epilepsia, 2005, 46(4): 470-472.

[2] Rosenow F, Luders H. Presurgical evaluation of epilepsy [J]. Brain : A Journal of Neurology, 2001, 124(9): 1683-1700.

[3] Bartolomei F, Chauvel P, Wendling F. Epileptogenicity of brain structures in human temporal lobe epilepsy: a quantified study from intracerebral EEG [J]. Brain : A Journal of Neurology, 2008, 131(Pt 7): 1818-1830.

[4] David O, Blauwblomme T, Job AS, et al. Imaging the seizure onset zone with stereo-electroencephalography [J]. Brain : A Journal of Neurology, 2011, 134(Pt 10): 2898-2911.

[5] Gnatkovsky V, de Curtis M, Pastori C, et al. Biomarkers of epileptogenic zone defined by quantified stereo-EEG analysis [J]. Epilepsia, 2014, 55(2): 296-305.

[6] Gnatkovsky V, Francione S, Cardinale F, et al. Identification of reproducible ictal patterns based on quantified frequency analysis of intracranial EEG signals [J]. Epilepsia, 2011, 52(3): 477-488.

[7] Acharya UR, Molinari F, Sree SV, et al. Automated diagnosis of epileptic EEG using entropies [J]. Biomed Signal Process Control, 2012, 7(4): 401-408.

[8] Diambra L, de Figueiredo JCB, Malta CP. Epileptic activity recognition in EEG recording [J]. Physica A, 1999, 273(3-4): 495-505.

[9] Rana P, Lipor J, Lee H, et al. Seizure detection using the phase-slope index and multichannel ECoG [J]. IEEE Transactions on Biomedical Engineering, 2012, 59(4): 1125-1134.

[10] Li YH, Ye XL, Liu QQ, et al. Localization of epileptogenic zone based on graph analysis of stereo-EEG [J]. Epilepsy Research, 2016, 128(1): 149-157.

[11] Sabesan S, Good LB, Tsakalis KS, et al. Information flow and application to epileptogenic focus localization from intracranial EEG [J]. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2009, 17(3): 244-253.

[12] Zalesky A, Fornito A, Cocchi L, et al. Time-resolved resting-state brain networks [J]. Proceedings of the National Academy of Sciences of the United States of America , 2014, 111(28): 10341-10346.

[13] Schreiber T, Schmitz A. Surrogate time series [J]. Physica D, 2000, 142(3-4): 346-382.

[14] Engel J. Intracerebral recordings - organization of the human epileptogenic region [J]. Journal of Clinical Neurophysiology, 1993, 10(1): 90-98.

[15] Bartolomei F, Lagarde S, Wendling F, et al. Defining epileptogenic networks: Contribution of SEEG and signal analysis [J]. Epilepsia, 2017, 58(7): 1131-1147.

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