北京生物醫(yī)學(xué)工程

個性化顱內(nèi)動脈瘤患者腦動脈血管三維容積重建及其應(yīng)用

Three-dimensional volume reconstruction of cerebral arteries for an individual patient with intracranial aneurysm and its application

作者：丁金立王海闊馬國峰張勇苗成鵬段云云張磊

單位：首都醫(yī)科大學(xué)附屬北京天壇醫(yī)院放射科（北京 100050）

關(guān)鍵詞：三維容積重建; 腦動脈瘤; 計算機(jī)斷層掃描血管造影; 平滑技術(shù); 迭代

分類號：R318.01

出版年·卷·期（頁碼）：2020·39·2（117-122）

摘要：

目的對個性化顱內(nèi)動脈瘤患者動脈瘤周圍腦動脈血管進(jìn)行三維容積重建，探索平滑迭代次數(shù)對三維模型的影響。方法針對個性化顱內(nèi)動脈瘤患者，通過Philips公司的256排iCT進(jìn)行計算機(jī)斷層掃描血管造影(computed tomography angiography, CTA)，基于256層頭部連續(xù)斷層圖像，利用Mimics商業(yè)軟件進(jìn)行三維圖像容積重建，獲取動脈瘤周圍動脈血管的三維解剖結(jié)構(gòu)，對重建模型表面進(jìn)行6次平滑處理，對比分析3D模型的瘤體直徑與2D切片圖像測得的瘤體直徑，評估3D模型的精確性。結(jié)果通過三維容積重建方法得到了動脈瘤周圍的頸內(nèi)動脈C2-C7段、大腦中動脈、大腦前動脈等血管的三維容積模型。平滑迭代次數(shù)為3時，模型表面較平滑，頸內(nèi)動脈血管直徑為3.82～5.64 mm，雙側(cè)大腦中動脈血管直徑2.31～3.83 mm，大腦前動脈血管可見多級分支，動脈瘤長徑14.70mm和短徑10.32mm。動脈瘤瘤體的長徑和短徑與2D圖像上的測量結(jié)果相比誤差均在4%以內(nèi)。結(jié)論利用三維容積重建技術(shù)所得的動脈瘤周圍腦血管模型提供了較二維圖像更直觀的解剖顯示和更好的后處理優(yōu)勢；過度平滑處理會導(dǎo)致三維重建模型尺寸與實際瘤體出現(xiàn)偏差，合理選擇平滑迭代次數(shù)對三維模型的精確重建具有實際意義。

Objective To carry out the three-dimensional volume reconstruction of cerebral arteries for an individual patient with intracranial aneurysm, and to discuss the influence of different iterations of smooth technology on the reconstrued model. Methods Philips 256 iCT was employed to perform computed tomography angiography (CTA), from which 256 slices were utilized for three-dimensional (3D) volume reconstruction by using the commercial software Mimics. Six iterations of smooth technology were performed on the reconstrued model. The longest and shortest diameters of the aneurysm was measured in the 3D model and compared with the results measured from 2D slices, to evaluate the precision of the smoothed models. Results The three-dimensional model of cerebral arteries and the intracranial aneurysms reconstructed after 3 iterations of smooth technology were measured. They included internal carotid artery of 3.82 mm-5.64 mm, bilateral middle cerebral artery of 2.31 mm-3.83 mm, multi-branches of anterior cerebral artery, intracranial aneurysm ( with longest diameter of 14.70 mm and shortest diameter of 10.32 mm). All the diameter-error ranges of the aneurysm were controlled within 4%. Conclusions The 3D model reconstructed by the volume reconstruction provides a more visual display than the original CT images. Application of excessive iterations of smooth technology increase the error of reconstrued model. Appropriate iterations of smooth technology is important for accurate 3D reconstruction.

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