北京生物醫(yī)學工程

基于系統(tǒng)矩陣的磁粒子成像重構(gòu)研究進展

Research progress on reconstruction for magnetic particle imaging based on system matrix

作者：陳曉君韓瀟王曉林李廣飛唐曉英

單位：北京理工大學生命學院(北京100081)

關(guān)鍵詞：醫(yī)學影像；磁粒子成像；系統(tǒng)矩陣；重構(gòu)；正則化

分類號：R318

出版年·卷·期（頁碼）：2020·39·2（196-202）

摘要：

磁粒子成像（magnetic particle imaging, MPI）是一種新型、前沿的層析成像方式，對具有生物相容性的超順磁納米粒子進行濃度分布成像，具有高靈敏度、高分辨率、無輻射等特征。基于系統(tǒng)矩陣的MPI重構(gòu)是MPI重構(gòu)研究的重要分支，較X-空間(X-Space)法具有更精確的重建效果。本文簡要介紹了MPI的成像及重構(gòu)原理；重點闡述了基于系統(tǒng)矩陣的MPI重構(gòu)研究現(xiàn)狀，對比分析了系統(tǒng)矩陣的測量與模型構(gòu)建方法，歸納總結(jié)了吉洪諾夫正則化、LASSO算法、非負的融合套索模型與聯(lián)合重建法的優(yōu)劣；最后針對公開的數(shù)據(jù)庫提出合理的頻率篩選、系統(tǒng)矩陣稀疏模型構(gòu)建、正則化方法探索改進的幾點研究建議，以期為MPI的重構(gòu)研究提供一定的方法參考，更好地促進未來磁粒子成像在臨床醫(yī)學中的良好應用。

Magnetic particle imaging is an emerging and frontier tomographic imaging modality that determines the concentration of biocompatible superparamagnetic nanoparticles with high sensitivity, high spatial resolution and no radiation. MPI reconstruction based on system matrix is an important branch of MPI reconstruction research, and has more accurate reconstruction effect than X-Space method. This paper briefly introduces the imaging principle of MPI and its reconstruction theory, and focuses on the MPI reconstruction progress based on system matrix, analyzes and compares the different methods for system matrix construction of measurement and model, summarizes the advantages and disadvantages of Tikhonov regularization method, LASSO algorithm, non-negative fused lasso model and joint reconstruction method. Finally, the paper proposes certain research suggestions for the open database, such as reasonable frequency screening, system matrix sparse model and regularization improvement method, expecting that this review may provide a convenience for researchers in MPI reconstruction and promote the future application of MPI in clinical medicine.

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