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目的  以雷洛昔芬干預(yù)治療骨質(zhì)疏松為對(duì)照，用生物力學(xué)性能指標(biāo)驗(yàn)證骨髓間充質(zhì)干細(xì)胞(bone mesenchymal stem cells ，BMSCs)干預(yù)治療骨質(zhì)疏松動(dòng)物的效果。方法 取6月齡雌性SD大鼠88只，隨機(jī)分為骨質(zhì)疏松動(dòng)物模型組22只，正常對(duì)照組22只，雷洛昔芬干預(yù)組22只，骨髓間充質(zhì)干細(xì)胞干預(yù)組22只。以摘除大鼠卵巢的方法建立骨質(zhì)疏松動(dòng)物模型。動(dòng)物飼養(yǎng)4周后，分別以骨髓間充質(zhì)干細(xì)胞和雷洛昔芬對(duì)骨質(zhì)疏松動(dòng)物進(jìn)行干預(yù)治療。于給藥6周后檢測各組大鼠血清Ca 、P 、堿性磷酸酶（alkaline  phosphatase,ALP），并取脛骨進(jìn)行剪切實(shí)驗(yàn),取股骨進(jìn)行沖擊實(shí)驗(yàn),測試肱骨的骨密度（bone mineral density，BMD）。結(jié)果 骨髓間充質(zhì)干細(xì)胞干預(yù)組肱骨BMD，血清Ca、ALP，脛骨各項(xiàng)剪切力學(xué)性能指標(biāo)和股骨各項(xiàng)沖擊力學(xué)性能指標(biāo)大于模型組及雷洛昔芬干預(yù)組,其血清P小于模型組及雷洛昔芬干預(yù)組（P<0.05）。結(jié)論 骨質(zhì)疏松動(dòng)物通過以骨髓間充質(zhì)干細(xì)胞干預(yù)后，肱骨BMD，血清Ca、ALP，骨的強(qiáng)度和韌性可以得到一定恢復(fù)。

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