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國(guó)產(chǎn)生物可吸收冠狀動(dòng)脈支架的研究現(xiàn)狀

Research status of domestic bioabsorbable coronary artery stents

作者: 李崇崇  王碩  萬辰杰  王春仁 
單位:中國(guó)食品藥品檢定研究院(北京 102629)
關(guān)鍵詞: 生物可吸收支架;冠狀動(dòng)脈;臨床試驗(yàn);器械設(shè)計(jì);經(jīng)皮冠狀動(dòng)脈介入治療 
分類號(hào):R318.08
出版年·卷·期(頁碼):2021·40·1(95-100)
摘要:

心血管介入治療技術(shù)是治療心血管疾病的重要手段,永久金屬支架雖然可以為冠脈狹窄提供支撐,但其在血管內(nèi)長(zhǎng)期存留可引起血管的慢性損傷,后期可造成血管中層萎縮、動(dòng)脈瘤形成以及反應(yīng)性內(nèi)膜增生,最終導(dǎo)致血管再狹窄。隨著科學(xué)技術(shù)的發(fā)展和實(shí)驗(yàn)的探索,生物可吸收支架正在逐步替代金屬永久支架,成為冠狀動(dòng)脈介入治療發(fā)展的新方向。國(guó)產(chǎn)冠脈支架的發(fā)展經(jīng)歷了模仿、改進(jìn)、創(chuàng)新的漫長(zhǎng)歷程,目前新型的生物可吸收冠狀動(dòng)脈支架已經(jīng)取得了可喜的階段性研究成果。本文綜述了幾種國(guó)產(chǎn)新型生物可吸收支架的發(fā)展情況,歸納其各自的特點(diǎn)和臨床試驗(yàn)結(jié)果,分析了當(dāng)前的問題,并對(duì)未來的發(fā)展做了展望。

Cardiovascular interventional therapy is an important means to treat cardiovascular diseases. Although permanent metal stent can provide support for coronary artery stenosis, its long-term retention in the vessel can cause chronic vascular damage, which can cause vascular medial atrophy, aneurysm formation and reactive intimal hyperplasia, eventually leading to vascular restenosis. With the development of technology and experimental exploration, bioabsorbable stents are gradually replacing metal permanent stents and become a new direction of coronary intervention. The development of domestic coronary stents has experienced a long process of imitation, improvement and innovation. At present, the new bioabsorbable coronary stents have achieved gratifying results. This paper reviews the development of several new domestic bioabsorbable stents, summarizes their respective characteristics and clinical trials, analyzes the current problems, and prospects the future development.

參考文獻(xiàn):

[1] 陳灝珠,林果維,王吉耀,等.實(shí)用內(nèi)科學(xué) [M]. 14版.上海:復(fù)旦大學(xué)出版社,2014:1466-1467.

Chen HZ, Lin GW, Wang JY, et al. Practical of internal medicine [M]. 14th ed.Shanghai:Fudan University Press,2014:1466-1467.

[2] 陶波,蔣學(xué)俊,方釗,等.冠狀動(dòng)脈生物可降解支架的研究現(xiàn)狀[J].中國(guó)心血管病研究,2016,14(4):289-292.

Tao B, Jiang XJ, Fang Z, et al.The research of biodegradable coronary artery stents[J].

Chinese Journal of Cardiovascular Research,2016,14(4):289-292.

[3] 唐熠達(dá),陳紀(jì)林.冠狀動(dòng)脈全降解支架的臨床研究進(jìn)展及展望[J].中國(guó)循環(huán)雜志,2016 ,31(5):417-419.

[4] 李家睿,馮邦哲,荊小馬.介入治療界的新星——生物可吸收支架[J].國(guó)際心血管病雜志,2018,45(3):136-138.

[5] 沈靂,葛均波.生物可吸收支架的利弊之爭(zhēng)[J].實(shí)用醫(yī)院臨床雜志,2017, 14(1):1-5.

Shen L, Ge JB. Advantages and disadvantages of bioresorbabel scaffold[J].Clinical Journal of Practical Hospital,2017, 14(1):1-5.

[6] 姜?jiǎng)P迪,王春仁,劉麗,等.基于聚乳酸及其共聚物的生物可吸收支架研究進(jìn)展[J].中國(guó)醫(yī)療器械信息,2019,25(1):42-45.

Jang KD, Wang CR, Liu L, et al.Current status and future direction of polymeric biodegradable vascular scaffolds[J].China Medical Device Information,2019, ,25(1): 42-45.

[7] 胡枝敏,凌望,吳美平. 支架植入后抑制平滑肌細(xì)胞過度增殖的研究進(jìn)展[J].中國(guó)醫(yī)藥導(dǎo)報(bào),2020, 17(7):33-36.

Hu ZM,Ling W,Wu MP. Research progress on inhibiting excessive proliferation of smooth muscle cells after stent implantation[J]. China Medical Herald,2020, 17(7):33-36.

[8] 郭振,尉海濤,劉全,等.可降解支架與金屬藥物洗脫支架對(duì)冠狀動(dòng)脈狹窄病變PCI術(shù)后安全性的影響[J].中國(guó)老年學(xué)雜志,2018,38(4):780-782.

[9] 高立建,陳紀(jì)林.生物可降解支架的臨床應(yīng)用進(jìn)展[J].中國(guó)循環(huán)雜志, 2017,32(3):215-216.

[10] 楊承志,喬樹賓.生物可降解冠狀動(dòng)脈支架研究進(jìn)展[J].中國(guó)循環(huán)雜志, 2015,30(12):1228-1230.

[11] 楊廣鑫,欒景源.生物可降解金屬血管支架研究進(jìn)展[J].中國(guó)微創(chuàng)外科雜志, 2018,18(8):753-760.

[12] Kerkmeijer LS, Tenekecioglu E, Wykrzykowska JJ.Stent thrombosis in patients with drug-eluting stents and bioresorbable vascular scaffolds: The feared complication[J]. Polish Archives of Internal Medicine-Polskie, 2018,128(1):943-950.

[13] Yamaji K, Ueki Y, Souteyrand G, et al. Mechanisms of very late bioresorbable scaffold thrombosis: The INVEST registry[J]. Journal of the American College of Cardiology, 2017,70(19): 2330-2344.

[14] Chevalier B, Cequier A, Dudek D, et al. Four-year follow-up of the randomised comparison between an everolimus-eluting bioresorbable scaffold and an everolimus-eluting metallic stent for the treatment of coronary artery stenosis (ABSORB Ⅱ Trial )[J]. Eurointervention, 2018,13(13):1561-1564.

[15] Kereiakes DJ, Ellis SG, Metzger C, et al. 3-Year clinical outcomes with everolimus-eluting bioresorbable coronary scaffolds the ABSORB Ⅲ trial[J]. Journal of the American College of Cardiology, 2017,70(23):2852-2862.

[16] Gogas BD, King SB, Samady H. Bioresorbable polymeric scaffolds for coronary revascularization: Lessons learnt from ABSORB Ⅲ, ABSORB China, and ABSORB Japan[J]. Global Cardiology Science & Practice, 2015,2015(5):62-69.

[17] 陶波,蔣學(xué)俊,方釗,等.冠狀動(dòng)脈生物可降解支架的研究現(xiàn)狀[J].中國(guó)心血管病研究,2016,14(4):289-292.

Tao B, Jiang XJ, Fang Z, et al. The research of biodegradable coronary artery stents[J]. Chinese Journal of Cardiovascular Research,2016,14(4):289-292.

[18] 宋雷,徐波.中國(guó)生物可吸收支架的研究與展望[J].中國(guó)心血管雜志,2019,24(6): 496-498.

Song L, Xu B. Research status and future perspectives of bioresorbable vascular scaffolds in China[J].Chinese Journal of Cardiovascular Medicine,2019,24(6): 496-498.

[19] 陶凌.NeoVas生物可吸收支架臨床研究結(jié)果報(bào)告[R].西安:曲江國(guó)際會(huì)議中心,2019.

[20] Han YL, Xu B, Fu GS, et al. A randomized trial comparing the NeoVas sirolimus-eluting bioresorbable scaffold and metallic everolimus-eluting stents[J]. JACC Cardiovascular Interventions, 2018,11(3):260-272.

[21] 365醫(yī)學(xué)網(wǎng).TCT 2018|韓雅玲院士解讀Neovas 可吸收系列研究結(jié)果[EB/OL].(2018-9-26). http://www.365heart.com/wap1/newwap1/shownews.asp?id=130884.

[22] 齊璐璐,沈靂,吳軼喆.自研生物可吸收支架獲批上市[N].健康報(bào),2020-3-16(2).

[23] 沈靂,葛均波.生物可降解支架的研究與展望[J].中華醫(yī)學(xué)信息導(dǎo)報(bào),2016,31(19): 17.

[24] 國(guó)家藥品監(jiān)督管理局.生物可吸收冠脈雷帕霉素洗脫支架系統(tǒng)產(chǎn)品獲批上市[EB/OL]. (2020-03-05).https://www.nmpa.gov.cn/directory/web/nmpa/yaowen/ypjgyw/20200305164201151.html.

[25] Wu Y,Shen L,Yin J,et al.Twelve-month angiographic and clinical outcomes of the XINSORB bioresorbable sirolimus-eluting scaffold and a metallic stent in patients with coronary artery disease[J]. International Journal of Cardiology,2019,293:61-66.

[26] 復(fù)旦大學(xué)附屬中山醫(yī)院.十年磨一劍,XINSORB生物可吸收支架獲批上市[EB/OL].(2020-02-12). http://www.zs-hospital.sh.cn/zsyy/n33/n66/u1ai4875.html.

[27] Song L, Sun ZW, Guan CD, et al. First-in-man study of a thinner-strut sirolimus-eluting bioresorbable scaffold (FUTURE-I): Three-year clinical and imaging outcomes[J]. Catheterization and Cardiovascular Interventions,2020, 95(1):648-657.

[28] Xu B. Firesorb PLLA-based sirolimus-eluting scaffold. transcatheter cardiovasc therapeutics[M]. Washington, DC. USA,2016-10-31.

[29] Xu B, Guan CD, Gao RL. A first-in-man study of the firesorb sirolimus target eluting bioresorbable vascular scaffold in patients with coronary artery disease(FUTURE-Ⅰ):Two-year clinical and imaging outcomes[J]. Chinese Circulation Journal,2018,33(S1):137.

[30] Song L, Sun ZW, Guan CD, et al. First-in-man study of a thinner-strut sirolimus-eluting bioresorbable scaffold (FUTURE-I): Three-year clinical and imaging outcomes[J].Catheterization and Cardiovascular Interventions,2020,95(Suppl 1):648-657.

[31] 高潤(rùn)霖,張澍,王增武,等.新中國(guó)成立七十年來我國(guó)心血管病學(xué)的發(fā)展[J].中國(guó)循環(huán)雜志,2019,34(9): 833-843.

Gao RL, Zhang S, Wang ZW, et al. The development of cardiology in China in 70 years since the founding of the people's republic of China[J].Chinese Circulation Journal,2019,34(9): 833-843.

[32] Zheng JF,Qiu H,Tian Y, et al. Preclinical evaluation of a novel sirolimus-eluting iron bioresorbable coronary scaffold in porcine coronary artery at 6 months[J]. JACC Cardiovascular Interventions, 2019: 12 (3):245-255.

[33] 竇克非.鐵基生物可吸收支架的特點(diǎn)和研究進(jìn)展[R].美國(guó)圣迭戈:圣迭戈會(huì)議中心,2018.

[34] Wu YJ, Sun ZW, Gao LJ, et al. A first-in-man study of the bioheart sirolimus-eluting bioresorbable vascular scaffold in patients with coronary artery disease: Six-month clinical and imaging outcomes[J]. Journal of the American College of Cardiology, 2017,70(18) SB:B7.

[35] Guan CD, Gao LJ, Sun ZW, et al. A first-in-man study of the bioheart sirolimus-eluting bioresorbable scaffold in patients with coronary artery disease: One-year clinical and imaging outcomes[J]. Journal of the American College of Cardiology, 2018, 72(13)SB:B158-B159.

[36] Ferdous M, Wu YJ, Guan CD, et al. A first-in-man study of the bioheart sirolimus-eluting bioresorbable scaffold in patients with coronary artery disease: 2-year clinical and imaging outcomes[J]. Journal of the American College of Cardiology, 2019,74(13) :B174.

[37] 沈瑩冉,周永新.生物可降解冠狀動(dòng)脈支架的研究進(jìn)展[J].外科研究與新技術(shù),2014,3(4):267-274.

Shen YR, Zhou YX. Progess of biodegradable coronary stents[J].Surgical Research and New Technique,2014,3(4):267-274.

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