北京生物醫(yī)學(xué)工程

同種異體與動(dòng)物源性補(bǔ)片的力學(xué)性能比較

Comparison of mechanical properties between allogeneic and animal derived patches

作者：李崇崇劉麗王碩韓倩倩王春仁李靜莉

單位：中國食品藥品檢定研究院(北京 102629)

關(guān)鍵詞：同種異體補(bǔ)片；豬源性補(bǔ)片；牛源性補(bǔ)片；力學(xué)性能

分類號(hào)：R318.01

出版年·卷·期（頁碼）：2021·40·2（181-184）

摘要：

目的比較同種異體和動(dòng)物源性補(bǔ)片的力學(xué)性能，為相關(guān)行業(yè)的產(chǎn)品研發(fā)和臨床使用提供參考。方法使用力學(xué)實(shí)驗(yàn)設(shè)備對(duì)同種異體補(bǔ)片、豬源性補(bǔ)片、牛源性補(bǔ)片的拉伸強(qiáng)度、斷裂伸長(zhǎng)率、縫合強(qiáng)度進(jìn)行測(cè)試，并對(duì)實(shí)驗(yàn)數(shù)據(jù)進(jìn)行統(tǒng)計(jì)分析。結(jié)果力學(xué)測(cè)試結(jié)果顯示，豬源性補(bǔ)片在拉伸強(qiáng)度和縫合強(qiáng)度兩個(gè)方面與同種異體補(bǔ)片無顯著差異（分別為9.31 MPa vs 9.37 MPa，P>0.05；24.48 N vs 22.18 N，P>0.05），而牛源性補(bǔ)片的拉伸強(qiáng)度較高（22.73 MPa，P<0.01），縫合強(qiáng)度較低（11.97 N，P<0.01），在斷裂伸長(zhǎng)率方面同種異體補(bǔ)片明顯高于兩種動(dòng)物源性補(bǔ)片(68.49% vs 40.18% vs 31.61%，P<0.01)。結(jié)論豬源性補(bǔ)片與同種異體補(bǔ)片具有部分的力學(xué)相近性，但同種異體補(bǔ)片在斷裂伸長(zhǎng)率方面與動(dòng)物源性補(bǔ)片具有顯著差異。

Objective To compare the mechanical properties of allogeneic and animal derived patches, so as to provide reference for product development and clinical use in related industries. Methods The tensile strength, elongation at break and suture strength of allogeneic, porcine and bovine patches were tested by mechanical experimental equipment, and the experimental data were statistically analyzed. Results The mechanical test results showed that there was no significant difference in tensile strength and suture strength between porcine and allogeneic patch (9.31 MPa vs 9.37 MPa, P > 0.05; 24.48 N vs 22.18 N, P > 0.05, respectively). The tensile strength of bovine patch was higher (22.73 MPa, P < 0.01), and the suture strength was lower (11.97 N, P < 0.01). The elongation at break of allogeneic patch was significantly higher than that of two kinds of animal derived patch (68.49% vs 40.18% vs 31.61%, P < 0.01). Conclusions Certain of the mechanical properties of porcine and allogeneic patch are similar, yet the elongation at break of allogeneic patch is significantly different from that of animal patches.

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