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隨著人工關(guān)節(jié)置換手術(shù)總數(shù)的不斷增長(zhǎng)，術(shù)后假體周圍感染(periprosthetic joint infection, PJI)的絕對(duì)數(shù)量也在增加。人工全膝關(guān)節(jié)置換(total knee arthroplasty,TKA)和人工全髓關(guān)節(jié)置換(total hip arthroplasty,THA)術(shù)后假體周圍感染的治療目前仍具有挑戰(zhàn)性。在現(xiàn)有的幾種治療方案中,一期植 入抗生素負(fù)載的骨水泥間隔物，二期再行假體植入被認(rèn)為是治療PJI的金標(biāo)準(zhǔn)⑴。但因其治療周期長(zhǎng)， 且需要行多次手術(shù)，使得相當(dāng)一部分的患者在植入間隔物后未再行二期手術(shù)植入新的假體。隨著間隔 物制作技術(shù)的成熟，已經(jīng)有越來越多的學(xué)者報(bào)道了保留抗生素骨水泥間隔物治療PJI取得了較為滿意 的臨床療效。本文綜述了抗生素骨水泥間隔物的材料特性、保留間隔物的臨床應(yīng)用現(xiàn)狀,歸納總結(jié)了臨 床療效，分析了目前其優(yōu)勢(shì)及缺點(diǎn)，并對(duì)未來的發(fā)展做了展望。

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