北京生物醫(yī)學工程

基于肺部多模態(tài)圖像診斷惡性肺結(jié)節(jié)的影響因素

Influencing factors of malignant pulmonary nodules based on lung multimodal images

作者：佟超馮巍韓勇李偉銘陶麗新郭秀花

單位：首都醫(yī)科大學公共衛(wèi)生學院(北京100069) 北京市臨床流行病學重點實驗室(北京100069) 通信作者:郭秀花.E-mail: [email protected]

關(guān)鍵詞：惡性肺結(jié)節(jié);危險因素;Logistic回歸;腫瘤

分類號：R318.04

出版年·卷·期（頁碼）：2022·41·1（38-41）

摘要：

目的探討多模態(tài)影像參數(shù)在判斷肺結(jié)節(jié)良、惡性中的應用價值。方法收集來自首都醫(yī) 科大學宣武醫(yī)院及北京市腫瘤防治研究所肺占位患者病例326例，包括115例良性病例,211例惡性病例。記錄多模態(tài)影像指標，包括結(jié)節(jié)大小、最大標準攝取值(maximum standard uptake value,SUVmax)、磨玻璃樣變、邊緣光滑、有暈征、分葉征、毛刺征、鈣化共計8個指標，通過多因素Logistic回歸分析篩選出基于肺部多模態(tài)圖像的惡性肺結(jié)節(jié)的影響因素。結(jié)果多因素Logistic回歸分析顯示，結(jié)節(jié)大小、 SUVmax、分葉征、毛刺征為惡性肺結(jié)節(jié)的危險因素，相應的OR值分別為1. 31 ( 1. 03 ~ 1. 65)、1. 10 (1.03-1. 18)、7. 27(3. 57~ 14. 82),3. 16(1. 47-6. 83) o結(jié)節(jié)鈣化為惡性肺結(jié)節(jié)的保護因素,OR值為 0. 13(0. 05-0. 32)。結(jié)論結(jié)節(jié)大、SUVmax值大、存在分葉征、存在毛刺征、結(jié)節(jié)無鈣化提示肺結(jié)節(jié)為惡性結(jié)節(jié)的可能性較大。

Objective To explore the value of multimodal imaging parameters in determining benign and malignant pulmonary nodules. Methods This study collected pulmonary occupying patients from Xuanwu Hospital of Capital Medical University and Beijing Institute of Cancer Prevention and Treatment. A total of 326 cases were collected in this study, including 115 benign cases and 211 malignant cases.Multi-modal imaging indicators were recorded, including nodule size, maximum standard uptake value (SUVmax), ground glass nodules, margin, halo, lobular, spicule, and calcification. Multivariate Logistic regression analysis was used to screen out the influencing factors of malignant pulmonary nodules based on multi-modal images. Results Multivariate Logistic regression analysis showed that nodule size, SUVmax, lobular and spicule were risk factors for malignant pulmonary nodules, and the corresponding OR values were 1.31(1.03-1.65), 1.10(1.03-1.18), 7.27(3.57-14.82), 3.16(1.47-6.83). Calcification was a protective factor for malignant pulmonary nodules, with an OR value of 0.13(0.05-0.32). Conclusions Large nodules, large SUVmax values, lobular signs, burr signs, and no calcification of the nodules suggest that lung nodules are more likely to be malignant nodules.

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