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基于指脈的血液黏度無(wú)創(chuàng)檢測(cè)的可行性分析

Feasibility analysis of non-invasive measurement of microvascular blood viscosity based on finger pulse

作者: 王雷  張新宇  楊琳  孟煜  
單位:北京工業(yè)大學(xué)醫(yī)院(北京&nbsp;100124) <p>北京工業(yè)大學(xué)環(huán)境與生命學(xué)部智能化生理測(cè)量與臨床轉(zhuǎn)化北京市國(guó)際科研合作基地&nbsp;(北京&nbsp;100124)</p> <p>通信作者:楊琳。E-mail:[email protected]</p> <p>&nbsp;</p>
關(guān)鍵詞: 血液黏度;光電容積脈搏波;血液生化指標(biāo);無(wú)創(chuàng)檢測(cè)  
分類號(hào):R318.04 <p>&nbsp;</p>
出版年·卷·期(頁(yè)碼):2022·41·1(68-72)
摘要:

目的 通過(guò)無(wú)創(chuàng)的微血管血液黏度與低切血液黏度之間的相關(guān)性,探究基于指脈的血液黏度無(wú)創(chuàng)檢測(cè)的可行性。 方法 首先采集被測(cè)者的靜脈血、指尖光電容積脈搏波及生理信息;然后使用指脈波形面積擬合微血管半徑,通過(guò)泊肅葉定律公式計(jì)算無(wú)創(chuàng)的微血管血液黏度;最后用SPSS軟件分析微血管血液黏度計(jì)算值與全血黏度的相關(guān)性以及血液黏度與基礎(chǔ)生理因素、血液生化因素之間的相關(guān)性。 結(jié)果 微血管血液黏度計(jì)算值與低切血液黏度呈正相關(guān)。體重、腰圍、體表面積、總膽固醇與微血管血液黏度計(jì)算值、低切血液黏度呈正相關(guān);高密度脂蛋白與微血管血液黏度計(jì)算值、低切血液黏度呈負(fù)相關(guān)。結(jié)論 通過(guò)指脈無(wú)創(chuàng)檢測(cè)出來(lái)的微血管血液黏度,與有創(chuàng)檢測(cè)出來(lái)的低切血液黏度之間的正相關(guān)性以及二者狀態(tài)變化規(guī)律的一致性表明,基于指脈的血液黏度無(wú)創(chuàng)檢測(cè)具有一定的可行性。

 

Objective To analyze the correlation between the calculated value of microvascular blood viscosity and the whole blood viscosity at a low shear rate, and to explore the feasibility of the non-invasive blood viscosity detection method based on the finger pulse. Methods  First,we collected venous blood, photoplethysmography and physiological information. Then,the pulse wave area was used to fit the microvascular radius, poiseuille law formula was used to calculate the microcirculation blood viscosity. Finally,the correlation between calculated values of microvascular blood viscosity and whole blood viscosity at a low shear rate, and the correlation between blood viscosity with basic physiological factors and blood biochemical factors were analyzed by SPSS software. Results The calculated value of microvascular blood viscosity was positively correlated with whole blood viscosity at a low shear rate. Body weight, waist circumference, body surface area and total cholesterol were positively correlated with the calculated value of microvascular blood viscosity and whole blood viscosity. High density lipoprotein was negatively correlated with the calculated values of microvascular blood viscosity and whole blood viscosity at a low shear rate. Conclusions The positive correlation and consistent state change between the microvascular blood viscosity detected by non-invasive method and the whole blood viscosity at a low shear rate detected by invasive method indicate that the non-invasive detection of blood viscosity based on finger pulse is feasible.

 

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