北京生物醫(yī)學(xué)工程

一種供液系統(tǒng)在線消毒方式的改進(jìn)與研究

Improvement and research of online disinfection method of a liquid supply system

作者：徐明明呂慶文白路花

單位：南方醫(yī)科大學(xué)生物醫(yī)學(xué)工程學(xué)院 (廣州510515)  南方醫(yī)科大學(xué)珠江醫(yī)院 (廣州510282) 通信作者：呂慶文，教授。E-mail: [email protected]

關(guān)鍵詞：集中供B液系統(tǒng)；模型設(shè)計(jì)；細(xì)菌污染；效果研究

分類號：R318

出版年·卷·期（頁碼）：2022·41·2（185-189）

摘要：

目的血透室集中供B液系統(tǒng)微生物時常難以控制，本文提出一種具有在線制、除臭氧、循環(huán)消毒及檢測殘余臭氧功能的B液供液裝置以減少微生物的污染及節(jié)約消毒時間。方法基于盡可能的模擬在配液、儲液、供液過程中的實(shí)際應(yīng)用，作者在康盛KCDS200-B型供液系統(tǒng)的基礎(chǔ)上按 1:20 的比例改造設(shè)計(jì)出集中供B液小型模擬裝置。裝置根據(jù)在配液過程中是否進(jìn)行臭氧消毒分為實(shí)驗(yàn)組和對照組并進(jìn)行各 4 個周期的對比實(shí)驗(yàn)。每天分別對裝置進(jìn)行水體采樣，通過統(tǒng)計(jì)其每毫升中細(xì)菌數(shù)量及變化來測試裝置的臭氧消毒效果。結(jié)果采用模型后對比康盛B液系統(tǒng)可節(jié)約消毒時間約3 h，在采用臭氧消毒后，裝置細(xì)菌含量明顯降低。消毒前和消毒后兩組數(shù)據(jù)對比明顯, 采用重復(fù)測量數(shù)據(jù)的兩因素多水平分析的統(tǒng)計(jì)學(xué)方法,具有統(tǒng)計(jì)學(xué)意義（P〈0.05）。結(jié)論集中供B液小型裝置實(shí)現(xiàn)了B液中微生物的控制要求，改善了B液的污染狀況，相比傳統(tǒng)消毒方式更加便捷。

Objective The microorganisms of the blood permeable chamber centralized supply B-liquid system are often difficult to control, and this paper proposes a B-liquid supply device with on-line system, except ozone, circulating disinfection and detection of residual ozone function to reduce microbial pollution and save disinfection time. Methods Based on the practical application of the simulation in the process of dispensing, reservoir and supply as far as possible, the author designs a small simulation device with centralized B-liquid according to the ratio of 1:20 on the basis of Kangsheng KCDS200-B liquid supply system. The device is divided into experimental group and control group according to whether ozone disinfection is carried out in the dispensing process. The two groups performed a comparative experiment of 4 cycles each. The device is sampled daily by measuring the number of bacteria per milliliter and changes to test the ozone disinfection effect of the device.Results Comparing Kangsheng B liquid system after using the model can save disinfection time of about 3 hours, and after the use of ozone disinfection, the bacterial content is significantly reduced. The comparison between the two sets of data before and after disinfection is obvious, and the statistical method of multi-level analysis of two factors of repeated measurement data is used, which is of statistical significance (P < 0.05).Conclusions The small device of centralized B-liquid realizes the control requirements of microorganisms in B-liquid, improves the pollution of B-liquid, and is more convenient than the traditional disinfection method.

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