北京生物醫(yī)學(xué)工程

彈簧圈填充密度對乙狀竇憩室內(nèi)血流動力學(xué)的影響

Effect of coil density on hemodynamics in sigmoid sinus diverticulum

作者：劉莉穆振霞薛曉飛黃素琴呂涵高斌趙鵬飛丁賀宇王振常

單位：北京工業(yè)大學(xué)環(huán)境與生命學(xué)院（北京100124） 首都醫(yī)科大學(xué)北京友誼醫(yī)院放射科(北京100050) 通信作者：高斌。E-mail：[email protected]

關(guān)鍵詞：搏動性耳鳴；血流動力學(xué)；憩室；彈簧圈；填充密度；有限元

分類號：R318.01

出版年·卷·期（頁碼）：2022·41·3（221-227）

摘要：

目的從血流動力學(xué)的角度，研究彈簧圈填充密度對乙狀竇憩室內(nèi)血流動力學(xué)的影響規(guī)律。方法首先根據(jù)一名搏動性耳鳴患者的CTA影像數(shù)據(jù)建立個性化的乙狀竇血管幾何模型，然后采用連續(xù)的3D Timoshenko梁單元對彈簧圈離散化，建立不同填充密度的彈簧圈模型，最后采用瞬態(tài)計(jì)算流體力學(xué)(computational fluid dynamics , CFD)方法研究彈簧圈栓塞后憩室內(nèi)血流動力學(xué)變化。采用血管壁面壓力、壁面剪切力、血流速度流線和憩室低流速區(qū)域體積占比等參數(shù)來對比不同填充密度下憩室的血流動力學(xué)變化。結(jié)果在低填充密度下隨著填充密度的增大，憩室平均壁面壓力和憩室平均壁面剪切力降低。高填充密度下，增大填充密度以上指標(biāo)變化不明顯。結(jié)論高的填充密度有利于憩室內(nèi)血栓形成的血流動力學(xué)環(huán)境，憩室內(nèi)低流速區(qū)域體積占比增大，有利于憩室內(nèi)血栓形成的血流動力學(xué)環(huán)境。

Objective To explore the effect of coil packing density on hemodynamics in diverticulum from the perspective of hemodynamics. Methods According to the CTA image data of a patient with pulsatile tinnitus, a personalized geometric model of sigmoid sinus vessel was established. Then the coil and stent models were established by finite element method. The coil centerline was meshed with an 3D Timoshenko beam element method. Coils model with different packing densities were established. Transient computational fluid dynamics (CFD) method was used to simulate the hemodynamics of diverticulum embolization with coils. The wall pressure, wall shear stress, blood velocity streamlines and the proportion of low flow velocity of diverticulum were analyzed and compared to evaluate the hemodynamic changes of diverticulum. Results At low packing density, the , increased with the increase of packing density, the wash of blood flow on blood vessel wall decreased with the increase of packing density. Under high packing density, the change of the above indexes was not obvious. Conclusions Higher packing density is conducive to the hemodynamic environment of thrombosis in diverticulum. The volume proportion of low velocity area in diverticulum increases, which is conducive to the hemodynamic environment of thrombosis in diverticulum.

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