北京生物醫(yī)學工程

血液黏性對脈搏波傳播特性影響的定量分析

Quantitative analysis of the influence of blood viscosity on pulse wave propagation characteristics

作者：盧意成李本森繆馥星龔文波

單位：寧波大學沖擊與安全工程教育部重點實驗室(寧波 315211) 寧波市中醫(yī)醫(yī)院王暉工作室(寧波 315000) 通信作者：繆馥星，教授。Email: [email protected].

關(guān)鍵詞：脈搏波；脈搏波傳播速度；血液黏性；流固耦合分析模型；數(shù)值模擬

分類號：R318.01

出版年·卷·期（頁碼）：2022·41·3（235-241）

摘要：

目的通過定量分析血液黏性對脈搏波傳播特性的影響，以期為血液黏性的無創(chuàng)檢測研究提供一種新的思路。方法假設(shè)血管為彈性薄壁圓管、血液為均質(zhì)牛頓流體，應(yīng)用多物理場仿真軟件COMSOL Multiphysics，建立血液-血管系統(tǒng)的有限元模型。采用雙向流固耦合方法，分別選取血液動力黏性系數(shù)0、0.002、0.004、和0.006 Pa?s，計算得到壓力脈搏波與軸向速度脈搏波曲線，從脈搏波峰值以及波速方面定量分析人體肱動脈中血液黏性對脈搏波傳播特性的影響。結(jié)果血液黏性對脈搏波波速的影響比較微弱，不同動力黏性系數(shù)下的波速差距僅在1%左右。血液黏性對能量的耗散作用會使脈搏波的波峰值減小，初步分析可知，當血液動力黏性系數(shù)在0 ~ 0.006 Pa?s時，血液黏性越大脈搏波峰值衰減幅度越大；且黏性系數(shù)每增大0.002 Pa?s，壓力脈搏波峰值衰減幅度增加約1.76%，軸向速度脈搏波峰值衰減幅度增加約1.20%，血管壁的變形程度減小約2.98%。結(jié)論研究結(jié)果可以為通過脈搏波進行血液黏性的無創(chuàng)檢測研究提供參考依據(jù)。

Objective To quantitatively analyze the effect of blood viscosity on pulse wave propagation ,and to provide a new idea for non-invasive detection of blood viscosity. Methods The finite element model of the blood-vessel system was created using COMSOL Multiphysics, assuming that the blood vessels were elastic thin-walled circular tubes and the blood was a homogeneous Newtonian fluid. The blood dynamic viscosity coefficients of 0 Pa?s, 0.002 Pa?s, 0.004 Pa?s, and 0.006 Pa?s were chosen to calculate the pressure pulse wave and axial velocity pulse wave curves using the bidirectional fluid-solid coupling method. The peak value and wave velocity were used to quantify the effect of blood viscosity on the pulse wave propagation characteristics in the human humeral artery. Results Blood viscosity had little effect on pulse wave velocity, and the difference of wave velocity under different dynamic viscosity coefficients was only about 1%. Blood viscosity's energy dissipation effect reduces the peak value of the pulse wave. According to preliminary analysis, the greater the blood viscosity, the greater the attenuation of the pulse wave peak value when the hemodynamic viscosity coefficient was in the range of 0- 0.006 Pa?s. If the viscosity coefficient increases by 0.002 Pa?s, then the peak attenuation amplitude of the pressure pulse wave increases by about 1.76%, the peak attenuation amplitude of the axial velocity pulse wave increases by about 1.20%, and the deformation degree of vascular wall was reduced by about 2.98% . Conclusions The results can provide a reference for the noninvasive detection of blood viscosity by pulse wave

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