北京生物醫(yī)學工程

不同彎曲程度血管中適形貼壁支架的力學行為仿真

Simulation of mechanical behavior of body-fitted stent in blood vessels with different curvature

作者：馬晨陽陳詩亮張愉喬愛科

單位：北京工業(yè)大學環(huán)境與生命學部(北京100124)。<br /> 通信作者: 喬愛科。E-mail: [email protected]

分類號：R318. 01

出版年·卷·期（頁碼）：2022·41·5（441-446）

摘要：

目的探討不同彎曲程度的狹窄血管中適形貼壁支架的力學行為以及對貼壁不良的改善效果。方法首先建立三種不同彎曲程度(彎曲度T=0.1、0.05和0)的狹窄血管，采用三維投影的方法獲得彎曲血管中的適形貼壁支架。模擬傳統(tǒng)支架和適形貼壁支架在未完全鈣化和完全鈣化斑塊血管中的壓握、擴張過程，分析斑塊上的應力水平并計算了間隔距離和殘留體積。結果與傳統(tǒng)支架相比，適形貼壁支架對未完全鈣化斑塊上的最大Von Mises應力減少了約1 MPa，對完全鈣化斑塊減少了約3 MPa。對彎曲度T=0.1、0.05和0的完全鈣化斑塊血管的間隔距離均值分別減少了1.2%、4.3%和5.8%，殘留體積分別減少了5.3%、42.5%和63.7%；對未完全鈣化斑塊血管的間隔距離均值分別減少了1.1%、5.6%和2.4%，殘留體積分別減少了-5.7%、23.1%和46.7%。結論適形貼壁支架對斑塊產(chǎn)生的Von Mises應力均低于傳統(tǒng)支架，其對不同彎曲程度血管的貼壁不良情況均有所改善且對彎曲程度較小的血管改善效果更好。

Objective To explore the mechanical performance of body-fitted stent in stenotic vessels with different curvature and the improvement effect of stent malapposition. Methods Three kinds of stenotic vessels with different curvature (curvature T= 0.1, 0.05 and 0) were modelled. The body-fitted stent in the curved vessel was structured by three-dimensional projection method. The crimping and expanding processes of conventional stent and body-fitted stent in vessels with cellular and calcified plaques were simulated. The Von Mises stress on the plaque was analyzed and the separation distance and residual volume were calculated. Results Compared with conventional stents, the maximum Von Mises stress of body-fitted stent on cellular plaque was reduced by about 1MPa and that on calcified plaque was reduced by about 3MPa, the mean separation distance of body-fitted stent to calcified plaques with curvature T= 0.1, 0.05 and 0 decreased by 1.2%, 4.3% and 5.8% respectively, and the residual volume decreased by 5.3%, 42.5% and 63.7% respectively. The mean separation distance in cellular plaques decreased by 1.1%, 5.6% and 2.4%, and the residual volume decreased by -5.7%, 23.1% and 46.7%, respectively. Conclusions The Von Mises stress of body-fitted stent on plaque is lower than conventional stent. It can weaken the malapposition, and has a better effect on the vessels with small curvature.

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