北京生物醫(yī)學工程

大鼠小梁網(wǎng)組織壓痕實驗有限元模擬研究

Finite element simulation study on indentation experiment of rat trabecular meshwork

作者：王川董建鑫張靜李林劉志成

單位：首都醫(yī)科大學燕京醫(yī)學院（北京101300），<br />徐州醫(yī)科大學醫(yī)學影像學院（江蘇徐州221004），<br />首都醫(yī)科大學生物醫(yī)學工程學院（北京 100069），<br />臨床生物力學應用基礎研究北京市重點實驗室（北京 100069）<br />通信作者：劉志成，教授，博士研究生導師。E-mail：[email protected]

關鍵詞：小梁網(wǎng)組織；彈性模量，有限元分析，壓痕實驗；Hertz模型

分類號：R318.01

出版年·卷·期（頁碼）：2022·41·5（454-457）

摘要：

目的原子力顯微鏡壓痕技術確定的大鼠小梁網(wǎng)組織彈性模量結果顯示，不同壓入部位彈性模量值存在較大的差別，為分析差別產生的原因，本文擬利用有限元方法模擬小梁網(wǎng)組織壓入力學行為。方法首先基于大鼠小梁網(wǎng)組織共聚焦斷層圖像，經(jīng)重建獲取小梁網(wǎng)組織的三維結構模型，給出適用于描述大鼠小梁網(wǎng)組織力學特性的一階Ogden模型參數(shù)；然后利用有限元分析模擬壓痕實驗獲取不同位置處小梁網(wǎng)組織彈性模量。結果構建了大鼠小梁網(wǎng)組織三維結構模型，給出了模擬原子力顯微鏡壓痕實驗的一階Ogden模型參數(shù)，有限元模擬獲取了不同壓入位置處的小梁網(wǎng)組織彈性模量范圍為38~1300 Pa。結論一階Ogden模型適用于小梁網(wǎng)組織壓痕實驗模擬。

Objective There is a large deviation between the elastic modulus of rat trabecular meshwork determined by atomic force microscope indentation technique. In order to analyze the causes of the deviation, the finite element method is used to simulate the Indentation mechanical behavior of trabecular meshwork. Methods First, based on the confocal sectional image of rat trabecular meshwork tissue, the three-dimensional structure model of trabecular meshwork tissue was obtained. The parameters of the first-order Ogden model suitable for describing the mechanical properties of rat trabecular meshwork were given.Then, finite element analysis was used to simulate the indentation experiment to obtain the elastic modulus of trabecular meshwork at different positions. Results The three-dimensional structure model of rat trabecular meshwork was constructed, and the parameter of the first-order Ogden model was given. The elastic modulus of trabecular meshwork at different indentation positions was obtained by finite element simulation, ranging from 38 to 1400 Pa. Conclusions In this study, the rat trabecular meshwork tissue indentation experiment is simulated based on the finite element method, and the first-order Ogden model parameters describing the mechanical properties of trabecular meshwork tissue are given. The results show that the first-order Ogden model is suitable for the experimental simulation of trabecular meshwork tissue indentation.

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