北京生物醫(yī)學工程

超聲引導下微波消融術治療甲狀腺良性結節(jié)療效的Meta分析

Meta-analysis of the efficacy of ultrasound-guided microwave ablation for benign thyroid nodules

作者：季陽王朝歆

單位：北京中醫(yī)藥大學東方醫(yī)院（北京 100078）<br />通信作者：王朝歆。E-mail: [email protected]

分類號：R318 

出版年·卷·期（頁碼）：2022·41·6（597-602）

摘要：

目的比較超聲引導下微波消融術與常規(guī)手術對甲狀腺良性結節(jié)的有效性與安全性，驗證微波消融術治療的優(yōu)越性。方法通過文獻檢索方法，篩選出超聲介入微波消融術治療良性的甲狀腺結節(jié)的隨機對照試驗（RCT）研究報道，檢索時段至2021年7月4日。評價指標包括總有效率、不良反應發(fā)生率等指標，評估兩種治療方法的優(yōu)劣。結果共納入15篇文獻項研究，總樣本量為1 376例，其中試驗組690例，對照組686例。分析表明，超聲介入微波消融術治療甲狀腺良性結節(jié)的總有效率優(yōu)于使用常規(guī)手術，并能顯著降低不良反應發(fā)生率。結論本文通過文獻檢索方式，比較微波消融術與常規(guī)手術對甲狀腺良性結節(jié)的有效性與安全性，發(fā)現(xiàn)微波消融術在治療方面療效確切，副作用少，值得臨床選用。

Objective To compare the efficacy and safety of ultrasound-guided microwave ablation with conventional operation in the treatment of benign thyroid nodules, and to verify the superiority of microwave ablation. Methods Randomized controlled trials (RCTS) of ultrasound interventional microwave ablation for benign thyroid nodules were screened from 2021 to July 4 by literature search. Evaluation indexes include total effective rate, incidence of adverse reactions and other indicators to evaluate the advantages and disadvantages of the two methods. Results A total of 15 literature studies were included, with a total sample size of 1376 cases, including 690 cases in experimental group and 686 cases in control group. The results showed that the total effective rate of microwave ablation was better than conventional operation in the treatment of benign thyroid nodules, and the incidence of adverse reactions was significantly reduced. Conclusions This paper compared the efficacy and safety of microwave ablation with conventional operation for benign thyroid nodules through literature search. It was found that microwave ablation has definite curative effect and few side effects, and is worthy of clinical application.

參考文獻：

[1] Wang H, Mehrad M, Ely KA, et al. Incidence and malignancy rates of indeterminate pediatric thyroid nodules[J]. Cancer Cytopathology, 2019,127(4):231-239.
[2] 陳茉,徐書杭,劉超.良性甲狀腺結節(jié)的熱消融治療進展[J]. 國際內分泌代謝雜志, 2019, 39(4): 248-252.?
Chen M, Xu SH, Liu C, et al. Advancement of thermal ablation on benign thyroid nodules[J]. International Journal of Endocrinology and Metabolism, 2019, 39(4): 248-252.
[3] 彭彩碧,文重遠,李競,等. 射頻消融豬甲狀腺毀損灶形成的實驗研究及意義初探[J]. 實用醫(yī)學雜志, 2005, 21(23): 2604-2606.?
Peng CB, Wen CY, Li J, et al. Experimental study on porcine thyroid lesion by application of radiofrequency ablation[J]. The Journal of Practical Medicine, 2005, 21(23): 2604-2606.
[4] 陳奎銘,王小平,沈睿,等.微波消融術結合定向皮內透藥法治療甲狀腺結節(jié)30例[J]. 中國中西醫(yī)結合外科雜志, 2016, 22(4): 362-366.
[5] 隋洋,吳鳳林,孫醫(yī)學.超聲引導下射頻消融甲狀腺結節(jié)的并發(fā)癥與預防方法探討[J]. 醫(yī)學影像學雜志, 2014, 24(1): 32-35.
Sui Y, Wu FL, Sun YX. Analysis and prevention of the complications of ultrasound-guided radiofrequency ablation for thyroid nodules[J]. Journal of Medical Imaging, 2014, 24(1): 32-35.?
[6] Lim HK, Lee JH, Ha EJ, et al. Radiofrequency ablation of benign non-functioning thyroid nodules: 4-year follow-up results for 111 patients[J]. European Radiology, 2013, 23(4): 1044-1049.
[7] 談景東,榮維國. 微波消融治療168例甲狀腺良性結節(jié)的臨床體會[J]. 中華腫瘤防治雜志, 2020, 27(15): 1259-1262,1268.
Tan JD, Rong WG. Clinical experience of microwave ablation in the treatment of 168 benign thyroid nodules[J].Chinese Journal of Cancer Prevention and Treatment, 2020, 27(15): 1259-1262,1268.
[8] Happel C, Korkusuz H, Kranert WT, et al. Combination of ultrasound guided percutaneous microwave ablation and radioiodine therapy for treatment of hyper- and hypofunctioning thyroid nodules[J]. Nuklearmedizin Nuclear Medicine, 2014,53(6): N48-N49.
[9] 胡昊,田甄,南群. 肺腫瘤微波消融治療效果影響因素的研究現(xiàn)狀[J]. 北京生物醫(yī)學工程, 2020, 39(6): 643-649.?
Hu H, Tian Z, Nan Q. Research status of influence factors in therapeutic effect of microwave ablation for lung tumors[J]. Beijing Biomedical Engineering, 2020, 39(6): 643-649.
[10] 王月,周著黃,吳水才. 基于超聲回波去相關成像的微波消融實時監(jiān)測[J]. 北京生物醫(yī)學工程, 2018, 37(6): 575-580.
Wang Y, Zhou ZH, Wu SC. Real-time monitoring of microwave ablation based on ultrasonic echo decorrelation imaging[J]. Beijing Biomedical Engineering, 2018, 37(6): 575-580.
[11] 金鑫荔,盧偉.甲狀腺結節(jié)射頻及微波消融治療——現(xiàn)狀及存在問題[J].臨床放射學雜志, 2017, 36(2): 295-297.
[12] 周著黃,吳薇薇,盛磊,等. 腫瘤熱消融影像導航技術研究進展[J]. 北京生物醫(yī)學工程, 2014, 33(4): 415-422, 429.
Zhou ZH, Wu WW, Sheng L, et al. Advances in image navigation techniques for tumor thermal ablation [J]. Beijing Biomedical Engineering, 2014, 33(4): 415-422, 429.
[13] 曹昱婷. 超聲引導下微波消融治療甲狀腺良性結節(jié)及對術后甲狀旁腺機能和喉返神經功能的影響[J]. 當代醫(yī)學,2020,26(29):42-44.
Cao YT. Ultrasound-guided microwave ablation for benign thyroid nodules and its effect on postoperative parathyroid function and recurrent laryngeal nerve[J]. Contemporary Medicine, 2020, 26(29): 42-44.
[14] 李顯峰. 超聲引導下微波消融治療甲狀腺良性結節(jié)的效果及安全性[J]. 醫(yī)學信息, 2020, 33(19): 107-109.
Li XF. Effect and safety of ultrasound-guided microwave ablation in the treatment benign thyroid nodules[J]. Medical Information, 2020, 33(19): 107-109.
[15] 孫先松. 多模態(tài)超聲引導下經皮微波消融術對甲狀腺良性結節(jié)患者甲狀腺激素水平的影響[J]. 實用中西醫(yī)結合臨床,2021,21(1):29-30.
[16] 林少建,張微微,黎洪浩. 超聲引導下微波消融治療甲狀腺良性結節(jié)的預后分析[J]. 中國醫(yī)學創(chuàng)新,2019,16(16):19-22.
Lin SJ, Zhang WW, Li HH. Prognostic analysis of ultrasound guided microwave ablation in the treatment of benign thyroid nodules[J]. Medical Innovation of China, 2019, 16(16): 19-22.
[17] 盧彩成,俞秀華. 超聲引導下微波消融治療甲狀腺良性結節(jié)臨床研究[J]. 中外醫(yī)學研究, 2018, 16(11): 150-151.
[18] 饒程義,康佳. 超聲引導下微波消融治療甲狀腺良性結節(jié)的臨床效果[J]. 現(xiàn)代養(yǎng)生（下半月版）, 2019(7): 154-155.
[19] 時瑞敏. 超聲引導下經皮微波消融治療甲狀腺良性結節(jié)的效果觀察[J]. 中國民康醫(yī)學, 2017, 29(24): 38-39.
[20] 高靜,李英華,袁媛,等. 超聲引導下微波消融術治療甲狀腺良性結節(jié)臨床效果[J]. 昆明醫(yī)科大學學報,2019,40(8): 78-82.
Gao J, Li YH, Yuan Y, et al. Clinical effects of ultrasound-guided microwave ablation in the treatment of benign thyroid nodules[J]. Journal of Kunming Medical University, 2019, 40(8): 78-82.
[21] 韓煒,王學義.超聲引導下微波消融治療甲狀腺良性結節(jié)[J]. 中國衛(wèi)生標準管理, 2021, 12(3): 53-56.
Han W, Wang XY. Ultrasound guided microwave ablation of benign thyroid nodules[J]. China Health Standard Management, 2021, 12(3): 53-56.
[22] 涂清衛(wèi).超聲引導下經皮微波消融治療甲狀腺良性結節(jié)的效果及對患者甲狀腺激素水平的影響[J]. 實用癌癥雜志, 2020, 35(12): 2085-2086.
[23] 王宇思. 超聲引導下經皮微波消融術在甲狀腺良性結節(jié)治療中的應用效果觀察[J]. 中國療養(yǎng)醫(yī)學,2018,27(6): 611-612.
[24] 蔣富兵. 超聲引導下微波消融術治療甲狀腺良性結節(jié)的臨床價值[J]. 臨床醫(yī)學工程, 2021, 28(5): 583-584.
Jiang FB. Clinical value of ultrasound-guided microwave ablation in the treatment of benign thyroid nodules[J]. Clinical Medical & Engineering,2021,28(5): 583-584.
[25] 朱榮峰. 超聲引導下經皮微波消融治療甲狀腺良性結節(jié)的有效性和安全性分析[J]. 影像研究與醫(yī)學應用,2020,4(21): 208-209.
[26] 袁才奇. 超聲引導下微波消融術治療甲狀腺良性結節(jié)的臨床效果[J]. 臨床合理用藥雜志, 2017,10(10C):132-133.
[27] 傅明,崔智娟,陳建發(fā),等. 超聲引導下微波消融治療甲狀腺良性結節(jié)近期臨床療效觀察[J].世界最新醫(yī)學信息文摘(電子版), 2019,19(21):7-9.
Fu M, Cui ZJ, Chen JF, et al. Ultrasound-guided microwave ablation for the treatment of benign thyroid nodules[J].World Latest Medicine Information(Electronic Version), 2019, 19(21): 7-9.
[28] 中國醫(yī)師協(xié)會甲狀腺腫瘤消融治療技術專家組，中國抗癌協(xié)會甲狀腺癌專業(yè)委員會，中國醫(yī)師協(xié)會介入醫(yī)師分會超聲介入專業(yè)委員會，等. 甲狀腺良性結節(jié)、微小癌及頸部轉移性淋巴結熱消融治療專家共識(2018版)[J]. 中國腫瘤,2018,27(10): 768-773.
Thyroid Tumor Ablation Experts Group of Chinese Medical Doctor Association, Chinese Association of Thyroid Oncology, Interventional Ultrasound Committee of Chinese College of Interventionalists, et al. Expert consensus on thermal ablation for thyroid benign ?nodes, microcarcinoma and metastatic cervical lymph nodes (2018 Edition)[J].China Cancer, 2018, 27(10): 768-773.
[29] 張海鵬,侯翔波,董海軍,等. 微波消融治療甲狀腺良性結節(jié)的臨床效果及對甲狀腺生理功能的影響[J]. 臨床醫(yī)學研究與實踐,2021,6(19):89-91.
Zhang HP, Hou XB, Dong HJ, et al. Clinical effect of microwave ablation for benign thyroid nodules and its influence on physiological function of thyroid[J]. Clinical Research and Practice,2021,6(19):89-91.

服務與反饋：

【文章下載】【加入收藏】

提示：您還未登錄，請登錄！點此登錄

51黑料吃瓜在线观看,51黑料官网|51黑料捷克街头搭讪_51黑料入口最新视频