北京生物醫(yī)學(xué)工程

海藻酸鹽基胃黏膜保護(hù)膠的理化性能研究

Investigation on the physical and chemical properties of alginate - based gastric mucosal protective gel

作者：王涵何牧野曾行楊敏一孟珠楊柳王春仁

單位：中國食品藥品檢定研究院（北京 102629）<br />中國藥科大學(xué)（南京 211198）<br />通信作者：王春仁。E-mail：[email protected]

關(guān)鍵詞：海藻酸鹽；胃黏膜保護(hù)膠；酸敏感性；觸變性；組織粘附性；屏障

分類號：R318

出版年·卷·期（頁碼）：2022·41·6（611-615）

摘要：

目的對海藻酸鹽基胃黏膜保護(hù)膠的理化性能進(jìn)行研究，考察其臨床應(yīng)用的可行性。方法進(jìn)行酸敏感性實(shí)驗(yàn)、抗酶降解實(shí)驗(yàn)、組織黏附力實(shí)驗(yàn)、觸變性能實(shí)驗(yàn)及酸屏障作用實(shí)驗(yàn)。結(jié)果海藻酸鹽基胃黏膜保護(hù)膠具有抗酸解及酶解的特性，可在體內(nèi)保持良好的形態(tài)；具有較好的組織黏附性及酸屏障隔離作用，可保護(hù)胃黏膜免受胃酸的刺激；具有良好的觸變性，使其具有易于可注射性且保持穩(wěn)定的形態(tài)不易流動擴(kuò)散的特性。結(jié)論海藻酸鹽基胃黏膜保護(hù)膠具有適用于胃黏膜創(chuàng)面修復(fù)的理化性質(zhì)，是一種具有臨床應(yīng)用可能性的新型醫(yī)療器械產(chǎn)品。

Objective To study the physical and chemical properties of alginate - based gastric mucosal protective gel and investigate its feasibility in clinical application. Methods Acid sensitivity test, anti-enzyme degradation test, tissue adhesion test, thixotropic property test and acid barrier effect test of the gastric mucosal protective gel were carried out. Results Alginate based gastric mucosal protective adhesive had the properties of acid hydrolysis resistance and enzymatic hydrolysis which could maintain a good shape in the body. It had good tissue adhesion and acid barrier isolation function which could protect gastric mucosa from the stimulation of gastric acid. This gel also had good thixotropy, making it easy to inject and maintain a stable form that is not easy to flow and spread. Conclusions Alginate - based gastric mucosal protective gel has physicochemical properties which are suitable for gastric mucosal wound repair. This gel is a new medical device with clinical application possibility.

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