北京生物醫(yī)學(xué)工程

醫(yī)療器械相關(guān)的肺損傷

Lung lesions related with medical devices

作者：王涵楊柳楊敏一曾行孟珠王召旭王春仁付海洋

單位：中國(guó)食品藥品檢定研究院（北京102629） <p>中國(guó)藥科大學(xué)（南京 211198）<br />通信作者：付海洋。E-mail：[email protected]</p>

關(guān)鍵詞：醫(yī)療器械；肺；損傷；安全性

分類號(hào)：R318.6

出版年·卷·期（頁(yè)碼）：2022·41·6（639-644）

摘要：

醫(yī)療器械的廣泛使用對(duì)人體健康發(fā)揮巨大作用，但是在有些情況下也會(huì)引起肺損傷，有些損傷甚至是不可逆的。病理學(xué)家、臨床醫(yī)生以及相關(guān)的研究者需要對(duì)醫(yī)療器械相關(guān)的肺損傷有所認(rèn)識(shí)。本文對(duì)常用醫(yī)療器械所致的肺損傷的臨床表現(xiàn)、可能機(jī)制及預(yù)防措施進(jìn)行歸納與總結(jié)，以期為相關(guān)人員提供參考。與肺損傷相關(guān)的醫(yī)療器械包括放射治療器械、體外循環(huán)和透析器械、呼吸醫(yī)療器械、心血管植入醫(yī)療器械、注射整形用醫(yī)療器械、骨科填充醫(yī)療器械等。然而，醫(yī)療器械產(chǎn)品種類繁多且發(fā)展迅速，本文并不能完全概括醫(yī)療器械產(chǎn)品相關(guān)的肺損傷。

Medical devices are widely used and play a great role in human health. But in some cases, medical devices can cause lung lesions. Furthermore, some lesions are reversible while the others are irreversible. It is important that pathologists, clinicians and related researchers are aware of the lesions related with medical devices. In this paper, the clinical manifestations, possible mechanisms and preventive measures of lung injury caused by commonly used medical devices were summarized and concluded, in order to provide reference for relevant personnel. Medical devices related with lung lesions include radiotherapy devices, extracorporeal circulation and dialysis devices, respiratory medical devices, cardiovascular implants, medical devices for injection plastic surgery, orthopedic filler medical devices, etc. However, due to the wide variety and rapid development of medical devices, this paper could not fully summarize all the lung lesions related with medical devices.

參考文獻(xiàn)：

[1] 高雅. 新醫(yī)改背景下我國(guó)醫(yī)療器械行業(yè)發(fā)展的思考[J]. 中國(guó)醫(yī)療器械信息, 2022, 28(7): 46-48.
Gao Y. Thoughts on the development of medical device industry in China under the background of new medical reform[J]. China Medical Device Information,2022,28(7): 46-48..
[2] 高偉, 李文志. 體外循環(huán)肺損傷的保護(hù)性策略[J]. 國(guó)際麻醉學(xué)與復(fù)蘇雜志, 2019, 40(8): 714-719.
Gao W, Li WZ. The protective strategies for lung injury induced by cardiopulmonary bypass[J]. International Journal of Anesthesiology and Resuscitation, 2019, 40(8): 714-719.
[3] 姜濤, 王瑞彬, 霍楓. 用于體外循環(huán)裝置的材料涂層技術(shù)綜述與展望[J]. 材料導(dǎo)報(bào), 2018, 32(13): 2304-2310, 2328.
Jiang T, Wang RB, Huo F. The review and prospect of cardiopulmonary bypass coating materials [J]. Materials Reports, 2018, 32(13): 2304-2310, 2328.
[4] 鄭坤, 張紅. 體外循環(huán)肺損傷機(jī)制與肺保護(hù)策略的研究進(jìn)展[J]. 中國(guó)醫(yī)藥導(dǎo)報(bào), 2016, 13(35): 32-35.
Zheng K, Zang H. Research progress of lung injury and lung protective strategies by cardiopulmonary bypass[J]. China Medical Herald, 2016, 13(35): 32-35.
[5] 楊立峰, 柯軍, 顏林,等. 血液透析器的生物相容性研究及其臨床應(yīng)用現(xiàn)狀[J]. 臨床醫(yī)學(xué)工程, 2012, 19(2): 320-322.
Yang LF, Ke J, Yan L, et al. Biocompatibility of hemodialyzers and clinical application[J]. Clinical Medical & Engineering, 2012, 19(2): 320-322.
[6] Itoh H, Ichiba S, Ujike Y, et al. A prospective randomized trial comparing the clinical effectiveness and biocompatibility of heparin-coated circuits and PMEA-coated circuits in pediatric cardiopulmonary bypass[J]. Perfusion, 2016, 31(3): 247-254.
[7] Hasegawa T, Oshima Y, Yokoyama S, et al. Clinical application of a new ternary polymer, SEC-1 coat for pediatric cardiopulmonary bypass circuits: a prospective randomized pilot study[J]. Perfusion, 2020, 35(8): 826-832.
[8] 夏露露. 放射性肺損傷及康復(fù)研究進(jìn)展[J]. 臨床與病理雜志, 2019, 39(6): 1342-1348.
Xia LL. Research progress in radiation-induced lung injury and rehabilitation[J]. ?International Journal of Pathology and Clinical Medicine, 2019, 39(6): 1342-1348.
[9] Denney L, Byrne AJ, Shea TJ, et al. Pulmonary epithelial cell-derived cytokine TGF-β1 is a critical cofactor for enhanced innate lymphoid cell function[J]. Immunity, 2015, 43(5): 945-958.
[10] Groves AM, Johnston CJ, Williams JP, et al. Role of infiltrating monocytes in the development of radiation-induced pulmonary fibrosis[J]. Radiation Research, 2018,189(3): 300-311.
[11] 姬巍. 放射性肺損傷的臨床及實(shí)驗(yàn)室研究[D]. 北京：中國(guó)協(xié)和醫(yī)科大學(xué), 2008.
Ji W. Clinical and laboratory study on risk factors predicting radiation pneumonitis [J]. Beijing: Peking Union Medical College, 2008.
[12] 楊依依,姚尚龍,尚游. 呼吸機(jī)相關(guān)性肺損傷發(fā)病機(jī)制研究新進(jìn)展[J]. 中華危重病急救醫(yī)學(xué), 2016, 28(9):861-864.
Yang YY, Yao SL, Shang Y. New progress of pathogenesis in ventilator-induced lung injury [J]. Chinese Critical Care Medicine, 2016, 28(9):861-864.
[13] Katira BH. Ventilator-induced lung injury: classic and novel concepts[J]. Respiratory Care, 2019,64(6): 629-637.
[14] Frank JA, Matthay MA. Science review: mechanisms of ventilator-induced injury[J]. Critical Care, 2003, 7(3): 233-241.
[15] Komoda S, Ozawa H, Yuasa T. Hydrophilic polymer embolism in the lung as an adverse event-autopsy case of thromboembolisms in multiple organs associated with heparin-induced thrombocytopenia[J]. Circulation Journal, 2018, 82(2): 606-607.
[16] Allan RW, Alnuaimat H, Edwards WD, et al. Embolization of hydrophilic catheter coating to the lungs: report of a case mimicking granulomatous vasculitis[J]. American Journal of Clinical Pathology, 2009, 132(5): 794-797.
[17] Mehta RI, Mehta RI, Solis OE, et al. Hydrophilic polymer emboli: an under-recognized iatrogenic cause of ischemia and infarct[J]. Modern Pathology, 2010, 23(7): 921-930.
[18] Rapkiewicz A, Hood B, Hutchins K. Fatal case of hydrophilic polymer emboli[J]. Journal of Forensic Sciences, 2016,61(S1): S268-S270.
[19] Mehta RI, Mehta RI, Choi JM, et al. Hydrophilic polymer embolism and associated vasculopathy of the lung: prevalence in a retrospective autopsy study[J]. Human Pathology, 2015, 46(2): 191-201.
[20] 馬季娜, 張中和. 器械相關(guān)性肺栓塞[J].中國(guó)實(shí)用內(nèi)科雜志, 2003, 23(9): 571-572.
[21] Yang L, Wu H, Lu L, et al. A tailored extracellular matrix (ECM) - mimetic coating for cardiovascular stents by stepwise assembly of hyaluronic acid and recombinant human type III collagen[J]. Biomaterials, 2021, 276: 121055.
[22] 王晨羽, 王曉軍, 俞楠澤, 等. 注射美容填充引起非血栓性肺栓塞——病例報(bào)告及文獻(xiàn)回顧[J]. 中國(guó)美容整形外科雜志, 2017, 28(11): 662-665.
Wang CY, Wang XJ, Yu NZ, et al. Non-thrombotic pulmonary embolism after cosmetic filler injection: a case report and literature review[J]. Chinese Journal of Aesthetic and Plastic Surgery, 2017, 28(11): 662-665.
[23] Duan Y, Zhang L, Li S, et al. Polyacrylamide hydrogel pulmonary embolism—a fatal consequence of an illegal cosmetic vaginal tightening procedure: a case report[J]. Forensic Science International, 2014, 238: e6-e10.
[24] Bois MC, Hu X, Roden AC, et al. Increasing pulmonary infiltrates in a 72-year-old woman with metastatic breast cancer[J]. Chest, 2014, 146(6): e208-e211.
[25] 孫雪東, 陳建東, 嚴(yán)一核,等. 硅膠注射隆乳術(shù)后導(dǎo)致肺栓塞并外源性過(guò)敏性肺泡炎一例及文獻(xiàn)綜述[J]. 中國(guó)全科醫(yī)學(xué), 2014, 17(4): 477-479.
Sun XD, Chen JD, Yan YH, et al. Pulmonary embolism and extrinsic allergic alveolitis following breast augmentation with subcutaneous injection of silicone gel: a case report and literature review[J]. Chinese General Practice, 2014, 17(4): 477-479.
[26] Purdy-Payne EK, Green J, Zenoni S, et al. A serious complication of illicit silicone injections: latent silicone embolization syndrome after incision and drainage of local injection site[J]. Surgical Infections, 2015, 16(4): 473-477.
[27] Xin L, Bungartz M, Maenz S, et al. Decreased extrusion of calcium phosphate cement versus high viscosity PMMA cement into spongious bone marrow-an ex vivo and in vivo study in sheep vertebrae[J]. The Spine Journal, 2016,16(12): 1468-1477.
[28] Razuin R, Effat O, Shahidan MN, et al. Bone cement implantation syndrome[J]. Malaysian Journal of Pathology, 2013,35(1): 87-90.
[29] 關(guān)繼奎, 趙麗, 姜嶼, 等. 聚甲基丙烯酸甲酯骨水泥充填治療骨損傷后的肺功能變化[J]. 中國(guó)組織工程研究, 2013, 17(25): 4727-4732.
Guan JK, Zhao L, Jiang Y, et al. Changes of pulmonary function after bone injury treated with polymethylme-thacrylic bone cement [J]. Chinese Journal of Tissue Engineering Research, 2013, 17(25): 4727-4732.
[30] Qing Y, Li R, Li S, et al. Advanced black phosphorus nanomaterials for bone regeneration[J]. International Journal of Nanomedicine, 2020, 15: 2045-2058.
[31] Kayat J, Gajbhiye V, Tekade RK, et al. Pulmonary toxicity of carbon nanotubes: a systematic report[J]. Nanomedicine: Nanotechnology, Biology and Medicine, 2011, 7(1): 40-49.
[32] Grunewald J, Eklund A, Katchar K, et al. Lung accumulations of eosinophil granulocytes after exposure to cornstarch glove powder[J]. European Respiratory Journal, 2003, 21(4): 646-651.
[33] 儲(chǔ)慧民, 陳曉敏, 何斌, 等. 心房顫動(dòng)射頻導(dǎo)管消融后急性肺水腫分析[J]. 心電與循環(huán), 2012, 31(1): 6-9.
Chu HM, Chen XM, He B, et al. Analysis of acute pulmonary edema after radiofrequency catheter ablation of ablation of atrial fibrillation[J]. Journal of Electrocardiology and Circulation, 2012, 31(1): 6-9.
[34] 孫源君. 心房顫動(dòng)導(dǎo)管消融術(shù)后肺靜脈狹窄的診治進(jìn)展[J]. 中國(guó)循環(huán)雜志, 2018, 33(9): 920-922.
Sun YJ. Progress in diagnosis and treatment of pulmonary vein stenosis after catheter ablation of atrial fibrillation [J]. Chinese Circulation Journal, 2018, 33(9): 920-922.
[35] 沈新月. 塑化劑DEHP可能通過(guò)氧化應(yīng)激和TGF-β1產(chǎn)生肺毒性作用[D]. 合肥：安徽醫(yī)科大學(xué), 2018.

服務(wù)與反饋：

【文章下載】【加入收藏】

提示：您還未登錄，請(qǐng)登錄！點(diǎn)此登錄

51黑料吃瓜在线观看,51黑料官网|51黑料捷克街头搭讪_51黑料入口最新视频