北京生物醫(yī)學(xué)工程

基于CT成像的冠狀動脈流固耦合分析

FluidSolid Coupling Analysis of the Coronary Artery Based on the CT Images

作者：錢秀清張曉慧王燕李宇劉志成

單位：首都醫(yī)科大學(xué)生物醫(yī)學(xué)工程學(xué)院（北京100069）

分類號：

出版年·卷·期（頁碼）：2010·29·4（331-335）

摘要：

目的基于冠狀動脈血管彈性特征，研究冠狀動脈管壁及其內(nèi)部血液流動的各力學(xué)參數(shù)的變化規(guī)律。方法根據(jù)健康人體冠狀動脈造影的CT圖像，用Mimics軟件三維重建冠狀動脈多分支結(jié)構(gòu)；利用有限元方法，構(gòu)建多分支血管計算模型。在假設(shè)血管壁為線彈性材料，血液流動為不可壓縮牛頓流體瞬態(tài)流動條件下，進(jìn)行血液及管壁的流固耦合分析，分析各參數(shù)的變化規(guī)律。結(jié)果冠狀動脈內(nèi)血液的流速在心臟舒張期達(dá)到最大；在冠狀動脈彎曲及分叉處，流速會出現(xiàn)低速區(qū)，血管壁出現(xiàn)較大變形及等效應(yīng)力。結(jié)論在進(jìn)行冠狀動脈粥樣硬化形成機(jī)理的研究中，應(yīng)考慮血管變形的影響。

Objective The mechanical parameters of blood flow and vascular wall for coronary artery are researched while the elastic property of the blood vessel is considered. Methods The geometry of coronary artery with branches was reconstructed using the software Mimics based on the CT images of coronary angiography for healthy human body. The mechanical property of vascular wall was simplified as the linear elasticity material and the flow of blood was taken as transient flow of an incompressible Newtonian fluid. Then, the solidfluid coupling model using the finite element method was used for analyzing the variations of the parameters. Results The numerical calculation results showed that the velocities of blood flow reached the maximum during the cardiac diastole. The lower velocityies of the blood flow, the bigger deformations and equivalent stresses of the vascular wall occured at the bent field of the blood vessel and neighborhood of the branches. Conclusions The deformation effect of the coronary artery wall should be considered while we are studying the mechanism of the coronary atherogenesis.

參考文獻(xiàn)：

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