北京生物醫(yī)學(xué)工程

握力刺激強(qiáng)度與運(yùn)動(dòng)皮層激活相關(guān)性的fMRI研究

Force of Squeezing Related to Motor Cortex Activation: A fMRI Study

作者：成學(xué)慧李海云

單位：首都醫(yī)科大學(xué)生物醫(yī)學(xué)工程學(xué)院（北京100069）

關(guān)鍵詞：功能磁共振成像；O形橡膠圈；握力；腦運(yùn)動(dòng)皮層；小腦

分類號(hào)：

出版年·卷·期（頁(yè)碼）：2010·29·1（30-34）

摘要：

目的研究握力刺激強(qiáng)度與運(yùn)動(dòng)皮層激活程度的相關(guān)性。方法 16例正常右利手受試者根據(jù)視覺(jué)刺激提示右手進(jìn)行固定頻率的三種不同握力運(yùn)動(dòng)，同時(shí)進(jìn)行BOLD fMRI 掃描，用spm5計(jì)算得到不同握力的腦激活區(qū)并比較差異。結(jié)果在三種不同握力運(yùn)動(dòng)中，對(duì)側(cè)主運(yùn)動(dòng)區(qū)、對(duì)側(cè)軀體感覺(jué)區(qū)、對(duì)側(cè)輔助運(yùn)動(dòng)區(qū)（SMA）和對(duì)側(cè)運(yùn)動(dòng)前區(qū)（PMC）明顯激活;同側(cè)激活區(qū)較小或者未見(jiàn)激活區(qū)；同側(cè)小腦激活區(qū)較對(duì)側(cè)明顯激活。隨著握力強(qiáng)度的增高，M1和S1 激活強(qiáng)度、范圍都提高；小腦激活程度有所降低。結(jié)論正常人手握力運(yùn)動(dòng)時(shí)腦皮質(zhì)運(yùn)動(dòng)網(wǎng)絡(luò)被激活，握力刺激強(qiáng)度與M1、S1的激活程度呈正相關(guān)。

Objective To study the brain functional activations under several grip force levels. Methods Functional MRI was performed in 16 healthy subjects who alternated between rest and squeezing rubber Oring task at fix frequency （1 Hz）at one of three force levels using right hand. Statistic the brain functional activations under different grip force levels and compare the results using spm5 software. Results For each force level, group analysis results revealed that the contralateral sensorimotor cortex（SMC）,supplementary motor area （SMA） , premotor area （PMC） were activated, and the ipsilaterals were smaller or none. Bilateral cerebellum were activated，and the ipsilateral was stronger. Increased force of squeezing is associated with increased contralateral sensorimotor cortex，but decreased cerebellum. Conclusion Cerebral cortical motor network was extensively activated during grip force movement in normal subjects. Motor cortex neurons show increased activity with increased force of movement.

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