北京生物醫(yī)學(xué)工程

基于MR圖像女性阿爾茨海默癥海馬紋理特征研究

Texture Characteristic Analysis of Hippocampus Based on MR Images of Female Patients with Alzheimer’s Disease

作者：周曉霞張景劉卓童隆正

單位：首都醫(yī)科大學(xué)生物醫(yī)學(xué)工程學(xué)院(北京100069)

關(guān)鍵詞：阿爾茨海默病；紋理特征；海馬

分類號：

出版年·卷·期（頁碼）：2010·29·3（230-234）

摘要：

目的基于MR圖像研究女性阿爾茨海默癥患者海馬紋理特征的改變。方法取阿爾茨海默癥(Alzheimer’s disease，AD)患者組、老年和青年對照組各9例女性樣本，提取海馬和均值、灰度不均勻性等紋理參數(shù)和海馬體積參數(shù)，測試各組間參數(shù)是否顯著不同，并測試紋理特征和體積的相關(guān)性。結(jié)果 AD組與老年對照組海馬和均值、灰度不均勻性以及體積顯著不同(p<0.05)，紋理參數(shù)與海馬體積顯著相關(guān)(r>0.5，p<0.01)。老年對照組和青年對照組各參數(shù)均未見顯著性差異。結(jié)論紋理參數(shù)可能反映AD腦組織的病理改變，海馬增齡性變化與AD病理改變有本質(zhì)不同。此項研究可能為AD早期診斷提供幫助。

Objective The aim of this paper is to investigate the changes of texture characters of bilateral hippocampus in magnetic resonance images (MRI) among female patients with Alzheimer’s disease (AD). Methods Nine pairs of bilateral hippocampal areas were extracted from AD, elderly controls (EC) and young controls (YC) respectively. Texture characteristic parameters were firstly calculated by using statistical texture analysis, and then the differences of texture characteristic parameters and hippocampal volumes among each two groups were compared. Finally, analysis of the correlation was finished between texture characteristic parameters and hippocampal volumes. Results The results demonstrated that the texture characteristic parameters of each lateral hippocampus and volumes of corresponding hippocampus had significant differences between AD and EC (p<0.05).Texture characteristic parameters were significantly related to the volumes of hippocampus respectively (r>0.5, p<0.01). The parameters between EC and YC were not significantly different. Conclusion The texture characteristics parameters may reflect the pathological changes of brain in patients with AD. The hippocampal changes according to aging and pathological changes of AD disease are essentially different. Our study may stand to benefit the early diagnosis of AD.

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