北京生物醫(yī)學工程

球囊過盈量與支架術后邊緣效應的關系探討

Relationship Between Balloon OverLength and Poststenting Edge Effect

作者：李少君李寧李志韜田野

單位：哈爾濱醫(yī)科大學附屬第二醫(yī)院心內(nèi)科（哈爾濱150081）

分類號：

出版年·卷·期（頁碼）：2010·29·4（384-387）

摘要：

目的分析球囊過盈量與支架術后邊緣效應的關系，為減少邊緣效應、有效控制支架后再狹窄提供有益的參考。方法 24只雄性雜種犬隨機分為兩組，分別應用3mm×12mm及3mm×15mm兩種規(guī)格的球囊于冠狀動脈內(nèi)置入3mm×12mm規(guī)格的不銹鋼支架，利用冠狀動脈造影及組織切片法分析不同球囊過盈量與支架術后邊緣血管損傷及遠期邊緣效應的相關性。結果冠脈造影提示術后即刻兩種過盈量的球囊對支架邊緣部位血管內(nèi)徑的影響無顯著差別，術后4周組織切片結果提示兩組球囊過盈量對支架兩端邊緣部位血管壁的損傷程度及遠期邊緣效應的發(fā)生率明顯不同，球囊過盈量與管壁損傷程度和遠期邊緣效應均呈顯著正相關關系（r=0.668,P<0.01）。結論球囊過盈量是導致支架術后邊緣效應的原因之一。

Objective In order to provide a useful reference for reducing the poststenting edge effect and restenosis, we investigated the relationship between balloon overlength and poststenting edge effect in vivo experiment . Methods Forty size 3mm×12mm balloonexpandable stainless stents were implanted in the coronary arteries of twentyfour dogs with size 3mm×12mm and size 3mm×15mm balloons respectively. Quantitative coronary angiography and histology were used to evaluate the relationship between balloon overlength and longterm edge effect. Results Quantitative coronary angiography showed that at the postoperative moment the vascular diameters at the stent edge were not significant different between two sizes of balloon overlength. However the histology results indicated the degree of peristent injury and edge effect differed significantly between two groups and were correlated positively with balloon overlength（r=0.668,P<0.01） in 4 weeks. Conclusion Balloon overlength contributes to post stenting edge effect.

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