北京生物醫(yī)學(xué)工程

動脈粥樣硬化動物模型大腦中動脈的力學(xué)特性

Mechanical Properties of Middle Cerebral Artery of Experimental Atherosclerosis Animal Model

作者：孫長江高明許東輝馬洪順

單位：孫長江（1963—），男，主管技師，主要從事生物醫(yī)學(xué)工程研究

關(guān)鍵詞：動脈粥樣硬化；大腦中動脈；力學(xué)特性；應(yīng)力松弛

分類號：

出版年·卷·期（頁碼）：2010·29·4（402-404）

摘要：

目的比較正常和動脈粥樣硬化動物模型大腦中動脈的應(yīng)力松弛力學(xué)特性，為臨床研究動脈粥樣硬化的發(fā)病機(jī)制提供生物力學(xué)參數(shù)。方法利用日本島津電子萬能試驗(yàn)機(jī)對正常和動脈粥樣硬化模型中各10個大腦中動脈血管樣本進(jìn)行血管壁拉伸試驗(yàn)，測試過程中應(yīng)變增加速度為0.5%/s，總測定時間為7200s，其間采集100個時間點(diǎn)的應(yīng)力松弛數(shù)據(jù)，并對每組中的20個數(shù)據(jù)進(jìn)行曲線擬合。結(jié)果正常和動脈粥樣硬化組大腦中動脈管壁應(yīng)力松弛曲線是以指數(shù)關(guān)系變化的，其中正常組7200s應(yīng)力松弛量為0.291MPa，動脈硬化組為0.193MPa。結(jié)論動脈粥樣硬化對大腦中動脈壁應(yīng)力松弛特性具有一定影響。

Objective To Compare with normal and atherosclerosis animal model cerebrum median artery stress relaxation mechanics characteristic, and provide the biomechanics parameters for the clinical research of atherosclerosis pathogenesis. Methods The tension tests of 20 cerebrum median artery samples, 10 samples came from atherosclerosis models and another 10 samples from normal models, were carried on using the date main island Tianjin electron universal testing machines. In test process, the strain increased at the speed of 0.5%/s. For each sample, 100 spots of stress relaxation data were gathered in 7200s survey time totally. For each model group, twenty spot stress relaxation data were used to carry on the curve fitting of stress relaxation. Results The artery wall stress relaxation curves of normal and atherosclerosis cerebrum median arteries changed in index relations consistently. During 7200s, the value of stress relaxation was 0.291MPa in normal model group and 0.193MPa in arteriosclerosis model group. Conclusion Atherosclerosis influences the wall stress relaxation characteristic of cerebrum median artery.

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