北京生物醫(yī)學(xué)工程

CaO-MgO-P2O5-SiO2-CaF2系統(tǒng)自硬性玻璃的研究

Study of CaO-MgO-P2O5-SiO2-CaF2 Self-Hardening Glass

作者：林蔚李曉生林剛劉立佳劉喜軍林楓徐文華劉昌勝

單位：齊齊哈爾大學(xué)材料科學(xué)與工程學(xué)院(黑龍江齊齊哈爾161006)

分類號(hào)：

出版年·卷·期（頁碼）：2010·29·6（566-570）

摘要：

為研究鈣離子、鎂離子在體內(nèi)環(huán)境中對(duì)自硬性玻璃結(jié)晶行為的影響，為自硬性生物活性玻璃的臨床應(yīng)用提供依據(jù)，本文設(shè)計(jì)了CaO-P2O5-SiO2-CaF2(Ca-glass)和CaO-MgO-P2O5-SiO2-CaF2(CaMg-glass)系統(tǒng)玻璃并使用模擬體液(simulated body fluid, SBF)進(jìn)行了研究。首先采用磷酸氫二氨［(NH4)2HPO4］/［NH4H2PO4］硬化液與Ca-glass、CaMg-glass制成硬化體，然后使用X射線衍射(XRD)、掃描電鏡(SEM)、失重、力學(xué)分析等方法, 研究硬化體在SBF中的結(jié)晶性、降解性和力學(xué)性能。實(shí)驗(yàn)結(jié)果表明,玻璃粉末與磷酸銨緩沖溶液反應(yīng)形成了磷酸銨鈣［(NH4)2·Ca(HPO4) 2·H2O］硬化體。硬化體經(jīng)過SBF浸泡，Ca-glass系統(tǒng)硬化體中部分磷酸銨鈣轉(zhuǎn)化成羥基磷灰石，而CaMg-glass系統(tǒng)硬化體仍然為磷酸銨鈣。Ca-glass與CaMg-glass硬化體在SBF中浸泡28天分別降解19.4%和31.3%，抗壓強(qiáng)度分別為93.14MPa和64.52MPa。鎂離子的歧化作用是導(dǎo)致Ca-glass、CaMg-glass硬化體結(jié)晶性能、降解性能以及力學(xué)性能差別的主要原因。

In order to provide the basis of clinical application for self-hardenning bioactive glass and investigate the effects of calcium and magnesium ions on crystallization behavior of the glasses in simulative body environment, the CaO-P2O5-SiO2-CaF2 (Ca-glass) and CaO-MgO-P2O5-SiO2-CaF2 (CaMg-glass) system bioglass was designed and studied using simulated body fluid (SBF). Firstly, the hardening bodies were prepared by mixing hardening solution of composite ammonia phosphate ［(NH4)2HPO4］/［NH4H2PO4］ with Ca-glass or CaMg-glass powder comparatively. Then, the crystallinity, degradability and mechanical property were studied using SBF solution by means of X-ray diffraction (XRD), scanning electron microscopy (SEM), weightlessness and mechanical analysis methods. The experimental results indicated that calcium ammonia phosphate ［(NH4)2·Ca·(HPO4)2·H2O］ was formed after being mixed glass powder with composite ammonia phosphate solution. Immerging in SBF solution, the CaMg-glass hardening body was still consisted of calcium ammonia phosphate, while parts of the calcium ammonia phosphate in Ca-glass hardening body was transformed into hydroxyapatite crystal. The degradation ratios of Ca-glass and CaMg-glass hardening bodys were 19.4% and 31.3% after being immerged in SBF solution for 28 days, with compressive strength of 93.14 MPa and 64.52 MPa respectively. The disproportionation of magnesium ions was the main reason for the differences of crystallinity and degradability as well as mechanical property between Ca-glass and CaMg-glass hardening bodies.

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