北京生物醫(yī)學(xué)工程

血管介入式全身熱療計(jì)劃軟件的研制

Development of Software for Treatment Planning in Interventional Whole Body Hyperthermia

作者：賈得巍劉靜

單位：           清華大學(xué)醫(yī)學(xué)院生物醫(yī)學(xué)工程系(北京100084)    

關(guān)鍵詞：血管介入式全身熱療；治療計(jì)劃軟件；房室模型；生物傳熱；COM組件；混合編程

分類(lèi)號(hào)：

出版年·卷·期（頁(yè)碼）：2010·29·6（613-619）

摘要：

血管介入式全身熱療有望在晚期和擴(kuò)散型腫瘤的治療中發(fā)揮重要作用，相應(yīng)臨床手術(shù)的高效實(shí)施需要發(fā)展治療計(jì)劃軟件來(lái)指導(dǎo)加熱劑量的精確給定。本文從已經(jīng)過(guò)驗(yàn)證的人體全身生物傳熱房室模型出發(fā)，開(kāi)發(fā)出一套基于C#.Net與Matlab COM組件的計(jì)算機(jī)軟件。在Matlab中完成熱量守恒和差分離散，實(shí)現(xiàn)人體全身熱效應(yīng)的數(shù)值計(jì)算和后處理功能；在C#.Net中通過(guò)Heath Carter體型及成分評(píng)估策略、IO文件操作、Solidworks豐富了前處理自定義操作、可視化效果后處理和報(bào)告功能。本軟件對(duì)全身熱療的基本問(wèn)題提出了系統(tǒng)化的解決方案并將其分解為前處理、計(jì)算、后處理等幾大模塊并建立了評(píng)估的基本流程，計(jì)算案例成功地將全身熱療計(jì)劃評(píng)估通過(guò)友好軟件用戶接口進(jìn)行了標(biāo)準(zhǔn)化。

Interventional whole body hyperthermia (IWBH) is a very promising way for the treatment of late stage and metastatic cancer.A highly efficiency IWBH operation requires to develop a treatment planning software in order to guide a precise delivery of heating dosage.Based on the well demonstrated compartment bioheat transfer model for the whole human body，this article successfully develops a software by way of C#.Net and Matlab COM technique.The Numerical analysis of energy conservation and finite difference，as well as post processing modules was established in Matlab.In C#.Net，the applications of Heath Carter somatype analysis，IO file manipulation，and Solidworks aided realized the visualization，post-processing and reporting function.The present system provided a systemic solution to the fundamental issues involved in WBH by classifying the task into several main categories such as preprocessing，analysis and postprocessing.The calculation cases further illustrated the standardized work flow for the treatment planning procedures.

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