A summary about the definition,development,structure characteristics and clinical application of ultrasound contrast agent (UCA) is presented firstly in this paper.Then,we concentrate to introduce the application status of UCA in ultrasound diagnosis and ultrasound treatment.The discussion about safety problem of UCA is following.Lastly the latest research progresses of nanobubble UCA are described.This paper will be very important to thoroughly understand the characteristic,application status and secure problems of UCA.
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