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目的 比較雙電極雙向脈沖刺激和單電極雙向脈沖刺激在神經(jīng)纖維傳導(dǎo)阻斷中的阻斷閾值以及對(duì)神經(jīng)纖維的損傷，并通過(guò)該研究為電刺激促進(jìn)脊髓損傷后下尿路功能重建的動(dòng)物實(shí)驗(yàn)選擇最優(yōu)的刺激模式。方法 以有限長(zhǎng)單根有髓神經(jīng)為研究對(duì)象，以?xún)蓷珓?dòng)物的有髓神經(jīng)纖維Frankenhaeuser-Huxley（F-H）模型為仿真研究基礎(chǔ)。結(jié)果 比較了單、雙電極在雙向?qū)ΨQ(chēng)方波以及雙向間歇方波作用下的阻斷閾值以及單雙電極在同樣的刺激條件下（包括刺激波形、頻率以及電流強(qiáng)度）產(chǎn)生的離子電流強(qiáng)度大小。結(jié)論 雙電極的阻斷閾值大于單電極的阻斷閾值。在相同的刺激條件下，雙電極雙向脈沖刺激對(duì)神經(jīng)的損傷程度小于單電極雙向脈沖刺激。

［1］Tai C，de Groat WC，Roppolo JR. Simulation analysis of conduction block in
unmyelinated axons induced by high-frequency biphasic electrical currrents［J］. IEEE Trans
Biomed Eng，2005，52(7)：1323-1332.
［2］Tai C，Roppolo JR，de Groat WC. Response of external urethral sphincter to high
frequency biphasic electrical stimulation of pudendal nerve［J］. Journal of Urology, 2005,
174: 782-786.
［3］Tsai SJ, Lew, Date HL.Treatment of detrusor-sphincter dyssynergia by pudendal nerve
block in patient with spinal cord injury［J］.Arch Phys Med Rehabil,2002,83:714-717.
［4］Honert C, Mortimer JT .The response of the myelinated nerve fiber to short duration
biphasic stimulating currents［J］. Ann Biomed Eng,1997,7: 117-125.
［5］Bhadra N, Kilgore KL. Direct current electrical conduction block of peripheral nerve［
J］. IEEE Trans Biomed Eng, 2004, 12(3):313-324.
［6］Zhang X, Roppolo JR, de Groat WC，et al. Mechanism of nerve conduction block induced
by high-frequency biphasic rec-tangular pulses［J］. IEEE Trans Biomed Eng, 2006, 53(12):
2445-2454.
［7］Zhang X, Roppolo JR, de Groat WC, et al.Simulation Analysis of Conduction Block in
Myelinated Axons Induced by High-Frequency Biphasic Rectangular Pulses［J］. IEEE Trans
Biomed Eng, 2006,53(7):1433-1436.
［8］沈強(qiáng)，邰常峰，蔣大宗.利用單電極不對(duì)稱(chēng)雙向脈沖刺激實(shí)現(xiàn)哺乳動(dòng)物有髓神經(jīng)纖維選擇性興奮的
仿真研究［J］.電子學(xué)報(bào)，2001,29(3):354-357.
［9］Tai C, Roppolo JR, de Groat WC.Block  of external  urethral sphincter contraction by
high frequency electrical stimulation of pudendal nerve［J］.Journal of Urology, 2004, 172:
2069-2072.
［10］湯黎明，劉鐵兵，常本康，等.神經(jīng)閾值實(shí)驗(yàn)分析方法的研究［J］.醫(yī)療衛(wèi)生裝備，2004,12:23-
25.
［11］McNeal，Donald R. Analysis of a model for excitation of myelinated nerve［J］. IEEE
Trans Biomed Eng, 1976,23：329-337.
［12］Shen Q, Tai CF, Jiang DZ. Selective stimulation of mammalian nerve fibers using
biphasic pulses［J］. Journal of XI’AN Jiao Tong University, 2000, 34(2):52-57.
［13］沈強(qiáng)，劉雪良，蔣大宗，等.利用雙向方波脈沖刺激實(shí)現(xiàn)神經(jīng)纖維選擇性興奮的雙電極方法［J］.
中國(guó)生物醫(yī)學(xué)工程學(xué)報(bào)，2001,20(6):534-540.
［14］于磊，陳安宇，任朝暉，等.利用單電極不對(duì)稱(chēng)雙向脈沖電刺激實(shí)現(xiàn)有髓神經(jīng)傳導(dǎo)阻斷的仿真研究
［J］.北京生物醫(yī)學(xué)工程，2008,27(1):33-36.
［15］張旭，邰常峰，馬斌榮.用高頻雙向脈沖電刺激實(shí)現(xiàn)有髓神經(jīng)傳導(dǎo)阻斷的仿真研究［J］.北京生物
醫(yī)學(xué)工程，2006,25(3): 280-284.
［16］Zhu JL, Shen Q, Jian DZ. Discharge patterns of neurons under sinusoidal current
stimulation［J］. Space Medicine and Medical Engineering, 2002,15(2):108-111.
［17］Bhadra N, Kilgore KL. Direct current electrical conduction block of Peripheral nerve
［J］. IEEE Trans  on Neural System and Rehabilitation Eng, 2004,12(3): 313-324.
［18］Yu L, Zhang X, Chen AY, et al. Simulation analysis of conduction block in myelinated
axons using three models［J］. IEEE Trans on Biomed Eng, 2008 ,2(1): 1729-1732.