北京生物醫(yī)學(xué)工程

肝組織超聲圖像特征參數(shù)與溫度相關(guān)性研究

Study on Correlation of Temperature and Liver Tissue Ultrasound Image Features

作者：楊春蘭白燕萍楊春秀吳水才盛磊劉振臨

單位：北京工業(yè)大學(xué)生命學(xué)院生物醫(yī)學(xué)工程中心（北京100124）

分類(lèi)號(hào)：

出版年·卷·期（頁(yè)碼）：2011·30·3（237-242）

摘要：

熱療過(guò)程中對(duì)組織溫度進(jìn)行實(shí)時(shí)無(wú)創(chuàng)監(jiān)測(cè)是近年來(lái)研究的熱點(diǎn)和難點(diǎn)。本文對(duì)新鮮離體豬肝進(jìn)行水浴加熱實(shí)驗(yàn)并采集超聲圖像；分析了固定感興趣區(qū)域數(shù)字減影圖像的灰度直方圖、灰度共生矩陣和灰度-梯度共生矩陣特征參數(shù)與溫度的相關(guān)性。分析結(jié)果表明，其中灰度均值、灰度標(biāo)準(zhǔn)差、灰度熵；4個(gè)方向（0°，45°，90°，135°）上的角二階矩、對(duì)比度、逆差矩、相關(guān)；灰度分布不均勻性、能量、混合熵、慣性在26～45℃范圍內(nèi)與溫度具有較高的相關(guān)性。以上11個(gè)圖像特征可為選擇測(cè)溫模型參數(shù)提供參考，并有望應(yīng)用于組織高溫?zé)岑熌虆^(qū)檢測(cè)等實(shí)際問(wèn)題。

Non-invasive real-time temperature monitoring of tissue is a difficult problem and hot issue in hyperthermia. In this paper, fresh in vitro porcine liver tissues were heated in water-bath and the ultrasound images were acquired. The correlation of temperature and features, including gray level histogram, gray level co-occurrence matrix and gray level-gradient level co-occurrence matrix extracted from differential ultrasound images was analyzed. The results showed that 11 features of image were high correlated with tissue temperature from 26℃ to 45℃. These features included the mean values, standard deviation and entropy based on gray level histogram, the angular second moment, contrast, inverse difference moment and correlation in four directions (0°，45°，90°，135°), un-uniformity, energy, mixed entropy and inertia. The proposed 11 image features can help to construct the model of temperature measurement, it may be used for coagulation detecting in hyperthermia.

參考文獻(xiàn)：

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