北京生物醫(yī)學(xué)工程

人工肝治療對(duì)重型病毒性肝病患者生存期的影響

Survival Analysis on Virus Liver Failure Patients Treated with Artificial Liver Support System

作者：武文芳杜菁張晶

單位：首都醫(yī)科大學(xué)生物醫(yī)學(xué)工程學(xué)院(北京 100069)

關(guān)鍵詞：病毒性肝病；人工肝；生存分析

分類號(hào)：

出版年·卷·期（頁碼）：2011·30·6（632-634）

摘要：

目的通過大樣本對(duì)照分析研究，探討人工肝支持系統(tǒng)(artificial liver support system, ALSS)治療對(duì)重型病毒性肝病患者生存期的影響。方法選擇重型病毒性肝病患者902例，將患者分為人工肝治療組507例和常規(guī)內(nèi)科治療對(duì)照組395例，記錄其診斷、分期等原始資料并進(jìn)行隨訪，采用Kaplan-Meier方法和Log rank以及Breslow檢驗(yàn)進(jìn)行生存情況分析。結(jié)果人工肝治療對(duì)急性和亞急性重型病毒性肝炎患者的生存時(shí)間有明顯影響，能夠延長(zhǎng)其生存時(shí)間；人工肝治療可以延長(zhǎng)乙型肝炎患者的生存時(shí)間，對(duì)戊型肝炎患者的短期生存率有影響；人工肝治療次數(shù)對(duì)患者生存時(shí)間也有明顯影響。結(jié)論人工肝治療能夠延長(zhǎng)急性和亞急性重型病毒性肝炎患者的生存時(shí)間，多次治療效果顯著優(yōu)于單次治療和內(nèi)科治療。

Objective To evaluate the efficacy of artificial liver support system (ALSS) in the treatment of virus liver failure patients in a large controlled clinic trial. Methods Nine hundred and two patients with virus liver failure enrolled were divided into an ALSS treatment group of 507 and a control group of 395 without ALSS treatment. The analysis of survival time was computed by the Kaplain-Maier method, and comparison among groups was done by Log-Rank and Breslow test. Results ALSS affected the survival time of acute and subacute virus liver failure patients and prolonged their survival time significantly. ALSS also prolonged the survival time of B liver failure patients and affected the short-term survival time of E liver failure patients. The number of times of ALSS effected on the survival time of liver patients obviously. Conclusions Multi-ALSS treatment prolongs the survival time of acute and subacute virus liver failure patients and is more effective than the standard medicinal liver care treatment. The treatment with ALSS for the liver failure patients is important and necessary.

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