北京生物醫(yī)學(xué)工程

腦組織射頻消融的有限元仿真與分析

Finite element simulation analysis of radiofrequency ablation in brain

作者：洪焦高宏建吳水才

單位：北京工業(yè)大學(xué)生命科學(xué)與生物工程學(xué)院（北京 100124）

分類號(hào)：

出版年·卷·期（頁碼）：2012·31·1（10-15）

摘要：

目的運(yùn)用有限元方法(finite element method，F(xiàn)EM)模擬顱內(nèi)病灶射頻消融過程中的溫度場分布，以合理有效利用熱療方案，提高射頻消融對(duì)顱內(nèi)病灶的治療效果。方法建立電導(dǎo)率不變和電導(dǎo)率隨溫度變化的兩種有限元模型，并對(duì)兩種模型的中心溫度、電場強(qiáng)度、熱生成率、比吸收率(specific absorption rate，SAR)，以及熱損傷區(qū)域進(jìn)行對(duì)比分析。結(jié)果對(duì)比電導(dǎo)率不變的有限元模型，在電導(dǎo)率隨溫度變化的情況下，電場強(qiáng)度減小，電流密度增大，中心溫度升高，熱損傷范圍增大；當(dāng)消融溫度接近100 ℃時(shí)電導(dǎo)率變化明顯，其對(duì)消融效果影響較大。結(jié)論射頻熱療手術(shù)中考慮隨溫度變化的組織參數(shù)有較高的臨床參考價(jià)值。

Objective To simulate the temperature distribution during radiofrequency ablation(RFA)of intracranial lesion by the finite element method(FEM). This thermotherapy might improve the treatment effectiveness of the RFA in intracranial nidus. Methods Two finite element models including the constant electrical conductivity model and the temperature-dependent conductivity model were built，and the key parameters including central temperature，electric field intensity，heat flux，specific absorption rate(SAR)and lesion size were compared. Results In the case of the temperature-dependent conductivity，the lower electric field intensity，the higher electric current density，the higher central temperature，and the bigger lesion size were obtained. The impact of the temperature-dependent conductivity on the radiofrequency ablation operation was great， especially when the central temperature was near to 100℃. Conclusions The temperature-dependent parameters provided important clinical reference values in the intracranial radiofrequency ablation operation.

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