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目的 通過還原-氧化方法使作為前軀體的Fe3O4納米顆粒具有Fe-Fe3O4核殼結(jié)構(gòu)，以作為磁靶向藥物載體。方法 在管式爐中以H2還原Fe3O4納米顆粒后，利用壓差作用下進(jìn)入的少量空氣緩慢氧化還原后物質(zhì)，以制備符合預(yù)期要求的Fe-Fe3O4核殼結(jié)構(gòu)納米粒子，并分析產(chǎn)物的X射線衍射（X-ray diffraction，XRD）、透射電子顯微鏡（transmission electron microscopy，TEM）和振動樣品磁強計（vibrating sample magnetometer，VSM）表征結(jié)果。結(jié)果 通過還原-氧化法制備的Fe-Fe3O4核殼結(jié)構(gòu)納米粒子，形狀近似球形，粒徑主要分布在60～100 nm，比飽和磁化強度達(dá)108emu/g，比Fe3O4納米顆粒高30emu/g，且穩(wěn)定性良好。結(jié)論 還原-氧化法制備的Fe-Fe3O4核殼結(jié)構(gòu)納米顆粒比前軀體磁性強，并具有較高的化學(xué)穩(wěn)定性和生物相容性。

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