北京生物醫(yī)學(xué)工程

用于功能性胃腸疾病治療的植入式電刺激系統(tǒng)及動物實驗研究

Development and experiment in vivo of an implantable electrical stimulation system for treatment of functional gastrointestinal disorders

作者：程思漫姜萍萍王永兵顏國正

單位：上海交通大學(xué)電子信息與電氣工程學(xué)院（上海 200240）

關(guān)鍵詞：功能性胃腸疾病；電刺激器；動物實驗；盲腸壓力

分類號：

出版年·卷·期（頁碼）：2012·31·4（391-397）

摘要：

目的研究可用于功能性胃腸疾病治療的植入式電刺激系統(tǒng)，通過動物實驗研究，探討不同刺激參數(shù)對胃腸道收縮活動的作用效果，為治療用刺激參數(shù)的優(yōu)化提供初步依據(jù)。方法系統(tǒng)由便攜式體外控制器和植入式體內(nèi)刺激器組成，體內(nèi)外通信采用無線模式。刺激脈沖參數(shù)及指令由體外控制器設(shè)定并發(fā)送至體內(nèi)刺激器，胃腸道收縮活動由體內(nèi)刺激器集成的壓力檢測模塊采集并發(fā)送至體外以供分析。通過電刺激豬盲腸實驗，分析不同刺激參數(shù)下盲腸壓力的變化，以評價刺激參數(shù)對盲腸收縮活動的作用效果。結(jié)果系統(tǒng)樣機工作正常，輸出刺激脈沖信號精確，壓力信息記錄準確。動物實驗表明，增加刺激脈沖寬度使盲腸收縮活動的幅度增大,增加刺激脈沖頻率使盲腸收縮活動的潛伏期縮短,增加刺激脈沖幅度同時縮短盲腸收縮活動的潛伏期并增大收縮幅度。結(jié)論該植入式電刺激系統(tǒng)參數(shù)設(shè)定范圍大，輸出脈沖信號精確并具備壓力檢測功能，便于進行功能性胃腸疾病治療刺激參數(shù)的篩選和驗證。動物實驗初步驗證了不同刺激參數(shù)對盲腸收縮活動的作用效果。

Objective To develop an implantable electrical stimulation system as an avenue for the treatment of functional gastrointestinal disorders (FGID). To investigate the effects of different stimulation parameters on the gastrointestinal contractile activity in vivo and provide primary basis for the optimization of the stimulation recipes. Methods The system was composed of a portable external controller and an implantable electrical stimulator and they communicated with each other through wireless mode. The stimulation parameters and instructions were sent from the controller to the stimulator while the pressure of the gastrointestinal contraction was recorded by the pressure detection module integrated in the stimulator and was sent to the external controller for the analysis. Action effects of different stimulation parameters on the cecal contraction were verified by the analysis of the pressure in pig’s cecum stimulation. Results The system outputted stimulation pulse signals and recorded pressure information with high accuracy. The experiment in vivo indicated that the amplitude of the cecal contraction increased as the stimulation pulse width increased. The latency of the cecal contraction decreased as the simulation pulse frequency increased. The latency decreased and the amplitude of the cecal contraction increased as the stimulation pulse amplitude increased. Conclusions This system provided accurate stimulation pulse signals within a wide range of parameters and was convenient for the selection and verification of the stimulation recipes for the treatment of FGID. The animal experiment verified initially the action effects of different stimulation parameters on the cecal contraction.

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