北京生物醫(yī)學(xué)工程

實(shí)用新型腹腔內(nèi)循環(huán)熱灌注系統(tǒng)的研制及其應(yīng)用

Development and application of a new intraperitoneal hyperthermic perfusionchemotherapy system

作者：劉鳳珍何美玲李蛟龔慶成侯曉彤

單位：首都醫(yī)科大學(xué)附屬北京安貞醫(yī)院(北京100029)

關(guān)鍵詞：腹腔熱灌注化療；體外循環(huán)；熱灌注機(jī)；腫瘤

分類號(hào)：

出版年·卷·期（頁(yè)碼）：2012·31·4（398-401）

摘要：

目的研制一種新型腔內(nèi)循環(huán)熱灌注系統(tǒng)并進(jìn)行初步臨床應(yīng)用，以解決國(guó)內(nèi)熱灌注化療設(shè)備入腔內(nèi)水溫高、灌注流量低的問題。方法利用心臟手術(shù)體外循環(huán)裝置，即人工心肺機(jī)的單一滾壓泵，變溫水箱的升溫部分，組合成腔內(nèi)熱灌注機(jī)。熱灌注系統(tǒng)由一次性腔內(nèi)熱灌注裝置和灌注機(jī)組成，其中熱灌注裝置包括熱灌注插管、灌注環(huán)路、腹腔壓力監(jiān)測(cè)管路、儲(chǔ)液器、變溫器。熱灌注機(jī)由灌注泵、變溫水箱、溫度、壓力和時(shí)間監(jiān)測(cè)儀組成。通過20例腔內(nèi)循環(huán)熱灌注化療的臨床應(yīng)用驗(yàn)證此系統(tǒng)是否達(dá)到設(shè)計(jì)要求。結(jié)果該腔內(nèi)循環(huán)熱灌注系統(tǒng)入腔內(nèi)水溫≤43℃時(shí)腹腔內(nèi)流出體外的水溫41.5～42.7℃，灌注流量2000～3000mL/min。結(jié)論該實(shí)用新型一次性腔內(nèi)熱灌注化療裝置和熱灌注機(jī)符合國(guó)際熱灌注化療標(biāo)準(zhǔn)，實(shí)用、安全、方便、有效，適合臨床推廣應(yīng)用。

Objective This paper described the design, development and application of a new type of cavity circulating perfusion chemotherapy system to solve the problems of the domestic equipments. Methods The new type of perfusion circulation system was developed from the devices and equipment for cardiac surgery, which consisted of a one-time cavity circulating system as perfusion devices, and a perfusion machine. The perfusion devices included a perfusion catheter, filling loops, intra-abdominal pressure monitoring pipelines, the reservoir and the temperature control unit. The perfusion machine consisted of the infusion pump, the variable temperature water tank, and the temperature, pressure and time monitor. Twenty patients were treated with the perfusion chemotherapy after the primary tumor cytoreductive surgery under general anesthesia, which verified the system was designed successfully.Results For the new type of cavity circulating perfusion chemotherapy system, water flew into the cavity at 43℃ and out of the abdominal cavity at 41.5℃, which complied with the international standards in the hyperthermic perfusion chemotherapy. Conclusions The new type of cavity circulating perfusion chemotherapy system was practical, safe, convenient and effective, which might be suitable for clinical applications.

參考文獻(xiàn)：

［1］Fujimoto S, Shrestha RD, Kokubun M, et al. Intraperitoneal hypertheric perfusion combined with surgery effective for gastric cancer patients with peritoneal seeding［J］.Ann Surg, 1988, 208: 36-41.
［2］Esquivel J. Technology of hyperthermic intraperitoneal chemotherapy in the United States, Europe, China, Japan, and Korea［J］. Cancer J, 2009, 15(3): 249-254.
［3］Kahokehr A, Sammour T, Soop M, et al. Intraperitoneal local anaesthetic in abdominal surgery-a systematic review［J］. Anz J Surg, 2011, 81(4): 237-245.
［4］Verweal VJ, van Ruth S, Witkamp A, et al. Long-term survival of peritoneal carcinomatosis of colorectal origin［J］. Ann Surg Oncol, 2005, 12: 65-71.
［5］Yonemura Y, Kawamura T, Bandou E, et al. Treatment of peritoneal dissemination from gastric cancer by peritonectomy and chemohyperthermic peritoneal perfusion［J］. Br J Surg, 2005, 92(3): 370-375.
［6］Deraeo M, Rossi CR, Pennacchioli E, et al. Cytoreductive surgery followed by intraperitoneal hyperthermic perfusion in the treatment of recurrent epithelial ovarian cancer: a phase II clinical study［J］. Tumori, 2001, 87: 120-126.
［7］Aarts F, Hendriks T, Boerman OC, et al. A comparison between radioimmunotherapy and hyperthermic intraperitoneal chemotherapy for the treatment of peritoneal carcinomatosis of colonic origin in rats［J］. Ann Surg Oncol，2007，14: 3274-3282.

服務(wù)與反饋：

【文章下載】【加入收藏】

提示：您還未登錄，請(qǐng)登錄！點(diǎn)此登錄

51黑料吃瓜在线观看,51黑料官网|51黑料捷克街头搭讪_51黑料入口最新视频