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Objective To explore the difference of grey matter&rsquo;s volumes between baseline and 3-year follow-up of mild cognitive impairment(MCI)patients in 3D magnetic resonance image.Methods Based on the method of voxel-based morphometry(VBM)，we processed the 3T subjects(n=19)of MCI at baseline and 3 years later obtained from ADNI.After image preprocessing，we got the smoothed whole brain gray matter(GM)and then tested the changes of GM in the three years.In addition，based on the analysis on the clinical statistics characteristics of 3-year follow-up data，the samples were divided into two groups as progressive MCI(PMCI)and stable MCI(SMCI).Then we compared the whole brain GM difference between PMCI and SMCI.Results The regions of GM loss over the 3-year follow-up were the bilateral cerebellum posterior lobe，the right cerebellar anterior lobe，the right temporal lobe，the right middle temporal gyrus，the right inferior frontal gyrus and the right parahippocampal.Compared with SMCI，PMCI group had GM loss in the left cerebellum posterior lobe，the right occipital lobe and the right anterior cingulate regions(P<0.005).Conclusions Based on magnetic resonance images，the VBM method could objeetively reveal the GM atrophy in certanin regions and these results provided some reliable imaging basis for the early diagnosis of Alzheimer&rsquo;s disease.