北京生物醫(yī)學(xué)工程

GABA能抑制環(huán)路對神經(jīng)元信噪比的調(diào)節(jié)作用_________

The regulatory role of GABAergic inhibition loop on signal to noise ratio of neurons

作者：劉治國周保琢梁振周逸峰

單位：           中國科學(xué)技術(shù)大學(xué)生命科學(xué)學(xué)院視覺研究實(shí)驗(yàn)室(合肥230027)    

關(guān)鍵詞：抑制；信噪比；GABA；Bicuculline；衰老

分類號：

出版年·卷·期（頁碼）：2013·32·1（28-32）

摘要：

目的研究初級視皮層內(nèi)抑制性環(huán)路與神經(jīng)元反應(yīng)信噪比之間的關(guān)系。方法通過胞外局部微電泳GABA及其受體拮抗劑Bicuculline改變神經(jīng)元的抑制水平，并采用胞外單細(xì)胞技術(shù)記錄神經(jīng)元對視覺刺激所發(fā)放的動作電位。本文分析并比較了65個貓的初級視皮層神經(jīng)元3種信噪比SNR、SNR1、mSNR在給藥前后的變化。結(jié)果當(dāng)施加GABA，自發(fā)放幅度降低，細(xì)胞的信噪比增加；當(dāng)施加Bicuculline，自發(fā)放幅度增高，細(xì)胞的信噪比降低。結(jié)論神經(jīng)系統(tǒng)內(nèi)的抑制環(huán)路活動水平與神經(jīng)元反應(yīng)信噪比密切相關(guān)，部分提高抑制水平在一定程度上可增加神經(jīng)元信噪比。提示可通過向特定腦區(qū)給予抑制性物質(zhì),以改善神經(jīng)系統(tǒng)由于抑制性輸入不足導(dǎo)致的功能衰退。

Objective To investigate the contribution of inhibitory circuit to the signal to noise ratio (SNR) of neurons.Methods We electrophoretically applied the inhibitory transmitter GABA and the GABAA antagonist Bicuculline to increase/decrease the level of inhibition imposed on the neuron and extracellularly recorded single unit response of that neuron to visual stimuli.Sixty-five neurons from Area 17 in anesthetized cats were included in our analysis.SNR,SNR1,and mSNR were compared with or without GABA and Bicuculline administration.Results GABA decreased the amplitude of spontaneous activity and increased the SNR,while Bicuculline increased the amplitude of spontaneous activity and decreased the SNR.Conclusions The activity level of inhibitory circuit in neural system correlated closely with the SNR of neurons and enhancing the inhibition level increased the SNR to some extent,which indicated that delivery of inhibitory substance into special brain area might improve neural system’s function due to insufficiency of inhibitory input,especially aging.

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