北京生物醫(yī)學(xué)工程

微生物代謝網(wǎng)絡(luò)模塊性與魯棒性分析_________

Analysis of microbial metabolic networks modularity and robustness

作者：李貴生鄭浩然

單位：           中國(guó)科學(xué)技術(shù)大學(xué)計(jì)算機(jī)科學(xué)與技術(shù)學(xué)院(合肥230027)    

關(guān)鍵詞：代謝網(wǎng)絡(luò)；模塊度；魯棒性；微生物

分類號(hào)：

出版年·卷·期（頁碼）：2013·32·1（47-52）

摘要：

目的模塊性和魯棒性是微生物代謝網(wǎng)絡(luò)的2個(gè)重要性質(zhì)，但對(duì)于模塊性和網(wǎng)絡(luò)的結(jié)點(diǎn)度分布間的關(guān)系、網(wǎng)絡(luò)魯棒性和物種環(huán)境間的關(guān)系等問題仍不清楚。方法基于KEGG的代謝數(shù)據(jù)庫，構(gòu)建了已有全基因組序列的1015種微生物代謝網(wǎng)絡(luò)，利用現(xiàn)有方法計(jì)算了代謝網(wǎng)絡(luò)的模塊性和魯棒性，分析了網(wǎng)絡(luò)模塊性和結(jié)點(diǎn)度分布、魯棒性和物種環(huán)境間的關(guān)系。結(jié)果微生物代謝網(wǎng)絡(luò)的模塊度顯著高于度序列相同的模擬隨機(jī)網(wǎng)絡(luò)，而其緊密度低于這些隨機(jī)網(wǎng)絡(luò)。生活環(huán)境變化性大的物種的環(huán)境魯棒性也較高，環(huán)境魯棒性好的物種在自身環(huán)境下的網(wǎng)絡(luò)魯棒性相對(duì)較差。結(jié)論代謝網(wǎng)絡(luò)的高模塊性不能完全由度序列分布情況來解釋，物種代謝網(wǎng)絡(luò)的魯棒性和其生活環(huán)境密切相關(guān)。

Objective Modularity and robustness are two important properties of microbial metabolic networks.Yet there are still some questions unanswered,such as the relationship between network modularity and the node degree distribution,the relationship between network robustness and the environments of the species.Methods In this paper,we reconstructe metabolic networks for 1015 sequenced microbial species based on KEGG database,compute the values of modularity and robustness.Results Modularity values of these networks are significantly higher than simulated networks which have the same degree sequences,and their closeness values are lower.Species living in more variable environments have higher environment robustness in simulated conditions.And genetic robustness values in their own environments are relatively low for species with high environment robustness.Conclusions High modularity of metabolic networks cannot be fully explained by network node degree distribution,and the network robustness is closely related with the organism’s living environment.

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