北京生物醫(yī)學(xué)工程

___________晚期糖基化終產(chǎn)物受體基因多態(tài)性與肥胖的關(guān)聯(lián)研究_________

An association study between the gene polymorphisms of receptor for advanced glycation end-products and obesity

作者：黃福華王瀅趙祥海陳金鳳王海茹楊松趙彥平陳燕春李莉沈沖陳鑫

單位：           南京市第一醫(yī)院心胸外科（南京210006）    

關(guān)鍵詞：晚期糖基化終產(chǎn)物受體；肥胖；BMI；關(guān)聯(lián)研究

分類號(hào)：

出版年·卷·期（頁(yè)碼）：2013·32·3（291-295）

摘要：

目的分析晚期糖基化終產(chǎn)物受體（RAGE）的遺傳變異與中國(guó)漢族人群肥胖的關(guān)系。方法研究對(duì)象來(lái)

自江蘇省某鄉(xiāng)鎮(zhèn)農(nóng)村地區(qū)，從18～62歲目標(biāo)人群14 469人中抽取 2 731人進(jìn)行流行病學(xué)調(diào)查人群資料；選

擇采用連鎖不平衡分析的方法，選取RAGE基因及其上游的3個(gè)tagSNPs rs1800624、rs204993和rs184003進(jìn)

行關(guān)聯(lián)分析。結(jié)果 rs1800624位點(diǎn)與肥胖的關(guān)聯(lián)有統(tǒng)計(jì)學(xué)意義，校正年齡、性別、體力活動(dòng)和收入等混雜

因素后，相加模型和顯性模型的比值比（OR值）及其95%可信區(qū)間（95%CI）分別為0.807(0.669~0.974)、

0.762(0.617~0.939)。進(jìn)一步按性別進(jìn)行分層分析，結(jié)果顯示，男性人群中，攜帶rs1800624突變T等位基

因型（AT+TT）者肥胖患病風(fēng)險(xiǎn)增加。不同基因型之間BMI水平比較也未發(fā)現(xiàn)上述3個(gè)SNPs變異與BMI數(shù)量性

狀存在關(guān)聯(lián)。結(jié)論 RAGE基因rs1800624與男性人群肥胖風(fēng)險(xiǎn)增加顯著關(guān)聯(lián)。

Objective To evaluate the association between three single nucleotide

polymorphisms (SNPs) of receptor for advanced glycation end-products (RAGE) gene and obesity

in Han Chinese population.Methods Totally 2，731 adult subjects aged 18-62 were recruited

from a rural population of 14，469 subjects in Jiangsu province by an epidemiological

stratification sampling approach. Linkage disequilibrium (LD) analysis was applied and three

tagging SNPs (tagSNPs) of RAGE gene，rs1800624，rs204993，rs184003 were selected for

genotyping and analyzing for the association with obesity.Results SNP rs1800624 had

significant association with obesity and OR (95%CI) were 0.807(0.669-0.974) and 0.762(0.617

-0.939) in additive model and dominant models after the adjustment for confounding factors

such as age，sex，physical activity index and income.Further stratification analysis by sex

indicated that individuals carrying T allele (AT+TT) of SNP rs1800624 had higher

susceptibility to obesity than CC genotype in male.No significant difference of BMI was

found between genotype variations of rs1800624，rs204993 and rs184003.Conclusions Our result

suggests that SNP rs1800624 of RAGE gene is associated with increased risk of obesity in Han

Chinese men，and further replication study would be warranted.

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