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新型人工肛門括約肌系統(tǒng)及初步動物實驗研究

New artificial anal sphincter system and preliminary animal experiment

作者: 翁曉靖  顏國正  克磊  張根福  王永兵  劉華  劉志強 
單位:上海交通大學(xué)醫(yī)學(xué)精密工程及智能系統(tǒng)研究所(上海200240)
關(guān)鍵詞: 肛門失禁;人工肛門括約肌;無線;經(jīng)皮能量傳輸系統(tǒng);動物實驗 
分類號:
出版年·卷·期(頁碼):2013·32·6(587-593)
摘要:

目的 研究可用于治療肛門失禁的植入式人工肛門括約肌系統(tǒng)(artificial anal sphincter system,

AASS)。方法 系統(tǒng)由體內(nèi)執(zhí)行、體外控制和經(jīng)皮能量傳輸3個模塊構(gòu)成,體內(nèi)外通過無線模式通信。當(dāng)體內(nèi)

直腸壁上壓力超出閾值后,向體外發(fā)送排便報警信號,患者通過體外控制模塊控制體內(nèi)執(zhí)行模塊打開或關(guān)閉

直腸,采用經(jīng)皮能量傳輸模塊為體內(nèi)電池充電。通過1例豬的動物實驗,評估在活體環(huán)境下系統(tǒng)各模塊的可

靠性和穩(wěn)定性。15d后將動物解剖,觀察組織變化并進行體內(nèi)的腹瀉實驗和血供實驗。結(jié)果 植入體內(nèi)后,體

外控制模塊可實時控制體內(nèi)執(zhí)行模塊的各項操作,通過經(jīng)皮能量傳輸充電3h,在體內(nèi)可持續(xù)工作24h。擬腹

瀉狀態(tài)下,對腸壁施加7.16kPa的壓力(正常肛腸靜息壓為6.26~9.47kPa),能有效抑制腸道內(nèi)容物滲漏。結(jié)

論 AASS可以模擬正常人體肛門括約肌功能,為嚴重肛門失禁的患者提供了一種新的治療方法。

Objective To develop a new implantable artificial anal sphincter system (AASS) for

the treatment of fecal incontinence.Methods The system was composed of internal execution

prosthesis,external control module and wireless transcutaneous energy transmission system

(TETS).Wireless communication was used for the data transmission between the internal and

external.Once the rectal pressure exceeded the threshold,an alarm signal was sent to the

external to remind the patient for defecation.Patients controlled the internal execution

prosthesis to open or close the rectum through the external control module and the internal

execution module was charged through TETS.The system was implanted into a pig to evaluate the

stability of each part.After 15 days the pig was dissected to observe the changes and the

diarrhea and rectum blood experiments were conducted in vivo.Results External control module

achieved the real-time control of internal execution prosthesis.The internal execution module

could sustainably work 24 h after charging 3 h through TETS.Diarrhea experiment showed that

when the pressure of 7.16kPa was applied on the intestinal wall (normal anorectal resting

pressure:6.26-9.47kPa),the prosthesis could effectively suppress the leakage of intestinal

contents.Conclusions AASS could simulate the function of normal sphincter,as a new solution

for patients with severe fecal incontinence.

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