北京生物醫(yī)學(xué)工程

基于無(wú)線充電技術(shù)的胃腸電刺激系統(tǒng)

Gastrointestinal stimulating system based on wireless charging technology

作者：李寶偉姜萍萍顏國(guó)正

單位：上海交通大學(xué)醫(yī)學(xué)精密工程及智能系統(tǒng)研究所(上海 200240)

分類(lèi)號(hào)：

出版年·卷·期（頁(yè)碼）：2013·32·6（624-631）

摘要：

目的設(shè)計(jì)一種新型的植入式胃腸道刺激系統(tǒng)，不僅具有刺激功能，還具有腸電和壓力檢測(cè)功能，可用于檢測(cè)胃腸道刺激的效果，同時(shí)增加無(wú)線能量供給，以實(shí)現(xiàn)刺激器的長(zhǎng)期植入。方法系統(tǒng)由體內(nèi)刺激模塊、體外控制模塊及無(wú)線能量傳輸模塊組成。體外控制模塊通過(guò)無(wú)線射頻將控制信號(hào)傳輸?shù)襟w內(nèi)刺激模塊，體內(nèi)刺激模塊的能量由體外能量發(fā)射裝置通過(guò)電磁耦合進(jìn)行供給。通過(guò)生物反饋控制檢測(cè)不同刺激參數(shù)對(duì)胃腸道收縮活動(dòng)的作用效果，實(shí)時(shí)調(diào)整刺激參數(shù)，輸出需要的刺激脈沖。以模擬心電信號(hào)模擬腸電信號(hào)，進(jìn)行了相關(guān)的體外實(shí)驗(yàn)。結(jié)果在體外實(shí)驗(yàn)中，系統(tǒng)可有效檢測(cè)到2~20次/min的模擬心電信號(hào)，并實(shí)現(xiàn)實(shí)時(shí)刺激參數(shù)修改輸出不同的刺激脈沖。該系統(tǒng)實(shí)現(xiàn)了電流檢測(cè)功能，監(jiān)測(cè)作用部分的胃腸電阻。經(jīng)皮無(wú)線能量在兩級(jí)線圈軸向距離為22mm時(shí)的接收充電穩(wěn)定功率最大為0.93W，體內(nèi)鋰離子的充電電流為180~240mA。結(jié)論系統(tǒng)可檢測(cè)到最大變化范圍的模擬腸電信號(hào)。驗(yàn)證電流的作用效應(yīng)為后續(xù)的恒流刺激模式提供參考。該系統(tǒng)的無(wú)線充電功能可滿(mǎn)足植入式刺激器長(zhǎng)期植入的能量需求。

Objective A new type of implantable electrical stimulation system is designed with the stimulating function and the function of intestinal signal and pressure detection in order to detect the result of electrical stimulation. And the function of wireless energy supply is added to insure that the stimulator can be long-time planted. Methods The system consists of internal stimulator, external controller and wireless energy transmitting modules. The control signal is transformed from external controller to internal stimulator through RF. The energy of the internal stimulator is captured from external transmitting devices by using electromagnetic couple technology. We detect gastrointestinal contraction under different stimulating parameters with biofeedback control technology. So we can adjust the stimulating parameters to output stimulating pulse we need. Results This system detects 2 to 20 cpm analogous electrocardiograph signals effectively for adjusting the parameter to produce different stimulating pulse in vitro. Meanwhile, we realize current detecting function and the detection of the gastrointestinal resistor stimulated. The maximum of received stable power in vivo is 0.93 W and the charging current can be 180 mA to 240 mA as the coil distance is 22 mm. Conclusions This system can detect the maximum variation range of simulated intestinal signal. Verification of the current action effects provides a reference for constant current stimulation mode in the future. The wireless charging function meets the energy requirement for the long-term implantation of the stimulator.

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