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Objective To investigate the effect of structural design of artificial disc on the biomechanical changes after disc replacement.Methods Based on clinical images, we built a three dimensional finite element model of human cervical spine, which was developed and validated by existing literature data to ensure an accurate calculation result.Then, two finite element models of Prestige LP and Discover were developed, as the representative of two different types of structural design, to simulate artificial cervical disc replacement.At last, cervical biomechanical changes in regular conditions before and after the replacement were calculated and analyzed.Results By comparing the calculated results and data from literature, we found artificial disc replacement surgery tend to increase the range of spine segment motion and excessive activity to the facet joints, which led to increased facet joint pressure and ligament tension.In the long run, artificial disc replacement surgery might lead to instability of the spine and surgical segment degeneration.Conclusions The motion range of unrestricted prosthesis is greater than that of restricted prosthesis.Appropriate limit for the range of motion may be more beneficial to the long-term outcome after artificial disc replacement.