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隨著干細(xì)胞和人類遺傳學(xué)研究的發(fā)展，患者特異細(xì)胞和組織模型已逐步進(jìn)入到應(yīng)用階段。本文概述了在心血管疾病遺傳模型方面利用多能干細(xì)胞的途徑，包括ES細(xì)胞系的基因修飾，特異疾病iPS細(xì)胞的生成，先祖細(xì)胞的分離擴(kuò)增等。以有效的方式利用這些干細(xì)胞模型，將推動(dòng)疾病機(jī)理和藥物治療研究。

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