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Objective Abnormal nerve fiber activation can cause many disorder diseases. Therefore, the study on action potential propagation and conduction block of unmyelinated nerve with electrical stimulation has great values for science research and clinical application. Methods Based on Hodgkin-Huxley model, we research on fiber blocking threshold and blocking mechanism of unmyelinated nerve under high frequency biphasic electrical stimulation. A measurement method for the recovery time of axon to the initial state after electrical stimulation is proposed in this paper. Results Larger diameter fibers tend to be blocked early than smaller nerve fibers under electrical stimulation. With the increase of frequency, the biggest block threshold is 12kHz to 16kHz. The high frequency stimulation produces constant activation of both sodium and potassium channels at the nerve fiber node under the block electrode, which causes the conduction block of nerve fiber. After the electrical stimulation, the recovery time of nerve fiber to the initial state increases with the increase of frequency. Conclusions This study reveals the blocking mechanism of unmyelinated nerve fiber, and the relationship between recovery time of axon to the initial state and the frequency of electrical stimulation after electrical stimulation. The results can provide more information for animal experiments and clinical applications.