北京生物醫(yī)學工程

牙髓干細胞培養(yǎng)及分化的研究進展

Research progress on culture and differentiation of dental pulp stem cells

作者：邵元元胡偉平袁夢桐

單位：                                 哈爾濱醫(yī)科大學附屬第二醫(yī)院口腔修復科(哈爾濱150086)            

關(guān)鍵詞：牙髓干細胞；培養(yǎng)；分化；誘導

分類號：

出版年·卷·期（頁碼）：2015·34·4（432-434）

摘要：

干細胞是未分化的細胞，具有自我更新、高度增殖及多向分化等特性。牙髓干細胞（dental pulp stem cell，DPSC）不僅具有干細胞的上述特性，而且具有取材方便、易于培養(yǎng)、易于冷藏等優(yōu)點。本文就DPSC與其他三種干細胞在培養(yǎng)多向分化潛能、分化誘導因素、向誘導性多功能干細胞（induced pluripotent stem cell，iPSC）的分化潛能以及在組織工程學中的應用進行比較，并討論DPSC的培養(yǎng)及分化優(yōu)勢。

Stem cells are undifferentiated cells, which have self-renewal, high proliferation and multi-lineage differentiation capabilities. The advantages of dental pulp stem cells (DPSC) are easy to be obtained, to be cultured and to be refrigerated. DPSC is compared with three other kinds of stem cells in the culture of multi-lineage differentiation potential, in the differentiation-inducing factors, in the potential of differentiating into induced pluripotent stem cells (iPSC), as well as in their applications of tissue engineering. And the advantages of the culture and differentiation of DPSC are discussed.

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