北京生物醫(yī)學(xué)工程

基于功能連接算法的斜視性弱視兒童靜息態(tài)功能磁共振成像的研究

Research on resting state fMRI of strabismus amblyopia children based on functional connectivity algorithms

作者：周震景斌王洪夏翃

單位：                                 首都醫(yī)科大學(xué)生物醫(yī)學(xué)工程學(xué)院(北京100069)            

關(guān)鍵詞：功能磁共振成像; 功能連接算法；斜視性弱視

分類號(hào)：

出版年·卷·期（頁(yè)碼）：2015·34·5（454-457）

摘要：

目的探索斜視性弱視兒童腦功能區(qū)及其功能連接的改變，揭示斜視性弱視的發(fā)生與腦功能改變的相關(guān)性。方法在靜息態(tài)下采集22位斜視性弱視兒童和10名健康兒童腦功能磁共振圖像，利用DPARSF軟件計(jì)算全腦與ROI功能區(qū)的連接系數(shù)，并應(yīng)用t檢驗(yàn)對(duì)實(shí)驗(yàn)組和健康對(duì)照組進(jìn)行組內(nèi)和組間功能連接系數(shù)分析。結(jié)果發(fā)現(xiàn)斜視性弱視兒童部分腦功能連接低于正常對(duì)照組的相應(yīng)腦區(qū)連接，這些功能區(qū)主要分布于枕葉、顳葉、小腦后葉、頂葉、額葉、扣帶回等腦區(qū)。結(jié)論基于靜息態(tài)的fMRI的腦功能連接算法可以反映斜視性弱視兒童視皮層的變化和多腦區(qū)神經(jīng)活動(dòng)的變化。

Objective This paper studied the changes of strabismus amblyopia children’s brain regions and functional connectivity, and revealed the correlation between the occurrence of strabismus amblyopia and changes in brain function. Methods Resting state fMRI of 22 strabismus amblyopia children and 10healthy children were collected, and the connection coefficients of the whole brain and ROI functional areas were calculated by DPARSF software. Functional connectivity factors between and within groups were analyzed by t test. Results Brain functional connectivity of patients with strabismus amblyopia was lower than normal children’s, mainly in occipital lobe, temporal lobe, posterior cerbellar lobe, parietal lobe, frontal lobe and cingulate gyrus. Conclusions Resting state connectivity algorithm of fMRI may reflect the changes of visual cortex and the changes of neural activities in multiple brain regions of strabismus amblyopia children.

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