北京生物醫(yī)學(xué)工程

力在細(xì)胞內(nèi)的物理傳遞

Physical delivery of intracellular stress

作者：新磊劉曉光任海軍劉波

單位：大連理工大學(xué)生物醫(yī)學(xué)工程系(遼寧大連116024)

關(guān)鍵詞：機(jī)械應(yīng)力；應(yīng)力信號轉(zhuǎn)導(dǎo)；細(xì)胞功能；物理傳遞

分類號：R318.04

出版年·卷·期（頁碼）：2016·35·1（87-93）

摘要：

機(jī)械應(yīng)力可以調(diào)控細(xì)胞增殖、遷移、分化等功能變化，這種細(xì)胞內(nèi)的應(yīng)力信號轉(zhuǎn)導(dǎo)研究主要集中于生物化學(xué)信號的傳導(dǎo)途徑，但應(yīng)力在細(xì)胞內(nèi)的物理傳遞過程對細(xì)胞功能也存在顯著影響。本文綜述了應(yīng)力在細(xì)胞內(nèi)的物理傳遞的信號機(jī)制研究現(xiàn)狀，包括細(xì)胞膜、細(xì)胞骨架、內(nèi)質(zhì)網(wǎng)以及細(xì)胞核的應(yīng)力物理傳遞及其變化的研究；同時介紹了研究應(yīng)力在細(xì)胞內(nèi)物理傳遞的相關(guān)技術(shù)，包括化學(xué)試劑干擾、理論計算及多種熒光蛋白技術(shù)，展示出了應(yīng)力在細(xì)胞內(nèi)物理傳遞的基本途徑。

Mechanical stress can regulate cell proliferation,migration,differentiation and other functions. The signal transduction research of intracellular stress mainly focuses on the biochemical signaling pathways,however,the physical delivery process of the stress within the cells has a significant effect on cell function. In this paper,the investigation of mechanotransduction in the intracellular physical delivery process are summarized,including the research on cell membrane,cytoskeleton,endoplasmic reticulum and nucleus. Related technologies including chemical reagent interference,theoretical calculation and fluorescence protein technology are also reviewed to figure out the basic pathways of physical delivery of intracellular stress.

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